Tox: antidotes Flashcards
Cholinergic poisoning
Atropine
ind: symptomatic bradycardia, excessive secretions
Black widow spider bite
Black widow antivenom
ind: persistent symptoms despite analgesia, pregnancy, very young/elderly
Hydrofluoric acid exposure
Calcium
Dermal application if local symptoms/burns, IV calcium if hypocalcemia or high concentration exposure.
Viper snake bite (rattlesnakes, copperheads, water moccasins)
CroFab
ind: progressive swelling, increased pain, coagulopathy, systemic symptoms
Cyanide poisoning
Hydroxocobalamin (B12) 5g IV
Alt: Nitrites (induces methemoglobinemia and may subsequently require methylene blue), sodium thiosulfate
(ind: suspicion in pt with acidosis, coma, seizures, hypoTN, ++lactate)
Iron overdose
deferoxamine
Digoxin toxicity
Digoxin specific Fab
ind: ventricular dysrhythmias, bradycardia not responsive to therapy, K>5.0 in acute ingestion, potentially massive OD
Benzo overdose
flumazenil
contraindicated if chronic use, co-ingestion of potentially seizure-inducing medication and elevated ICP
Ethylene glycol overdose
Fomepizole
Ethanol
Thiamine (B1)
Pyridoxine (B6)
Methanol
Fomepizole
Ethanol
Folate
CCB or BB overdose
Calcium gluconate/CaCl
High dose insulin and dextrose
Glucagon
(ind: symptomatic bradycardia, hypotension)
Methemoglobinemia
Methylene blue
ind: levels >30%, mental status changes, CP, SOB
Tylenol overdose
N-acetylcysteine
(ind: acute ingestion as per Rumack-Matthew nomogram, unknown time or repeated supratherapeutic ingestion, elevated ALT/AST, APAP level >10microg/mL)
Opioid overdose
naloxone
ind: respiratory depression
Sulfonylurea overdose
Octreotide
ind: recurrent hypoglycemia