ToRCHeS infections

Question 1

ToRCHeS infections

Answer 1

Pass from mother to fetus
Most is transplacental or via delivery (esp HSV2)
Nonspecific signs: HSM, jaundice, thrombocytopenia, growth retardation.

Other important agents: GBS, ecoli, listeria => all of them cause meningitis in neonates

Parvo 19 causes hydros fetalis

Question 2

Toxo

Answer 2

Transmission: cat feces or undercooked meat

Mother: usually asympt, LAD rarely

Neonate: classic triad of chorioretinitis, hydrocephalus, and IC calcification

Question 3

Rubella

Answer 3

Transmission: respiratory droplet

Mother: rash, LAD, arthritis

Neonate: classic triad of PDA, cataract, deafness +/- blueberry muffin rash

Question 4

CMV

Answer 4

Transmission: sexual contact, transplant

Mother: usually asympt, mono illness

Neonate: hearing loss, seizure, petechial rash, blueberry muffin rash

Question 5

HIV

Answer 5

Transmission: sexual contact, needle stick

Mother: variable depending CD4

Neonate: recurrent infection, chronic diarrhea

Question 6

HSV2

Answer 6

Transmission: skin, mucous membrane

Mother: usually asympt, herpetic lesions

Neonate: encephalitis, herpetic lesions

Question 7

Syphilis

Answer 7

Transmission: sexual contact

Mother: chancre, disseminated rash are the two stages likely to result in fetal infection

Neonate: often results in stillbirth, hydrops fetalis. If child survives, presents with facial abn (notched teeth, saddle nose, short maxilla) saber shin, CN VIII deafness.