Systemic mycoses

Question 1

Systemic mycoses

Answer 1

all can cause pneumo, and disseminate.
All caused by dimorphic, except for coccidio, which is a spherule (not yeast) in tissue

Treat with fluconazole or itraconzole for local infection, but must use amphotericin B for systemic.

Systemic infection can mimic TB with granuloma fomration but no person to person transmission

Question 2

Histoplasmosis

Answer 2

Mississipi and Ohio River Valley
Macropahges filled with histoplasma (smaller than RBC)

Histo hides in macrophages.
Birds or bat dropping

Question 3

Blastomycosis

Answer 3

East of mississipi river and centra america
Form granumolatous nodules
Broad base budduing (same size as RBC)

“Blasto buds broadly”

Question 4

Coccidio

Answer 4

Southwestern
Pneumonia and meningitis.

Spherules filled with endosmores, much larger than RBCs

Coccidio crowds
San Joaquine Valley or desert (desert bumps)

Question 5

Paracoccidio

Answer 5

Latin America
Budding yeasts with Captain’s wheel formation (much larger than RBC)

Captain wheels appearance

“Paracoccidio parasails with the captain’s wheel all the way to Latin America”