Topoisomerase Inhibitors

Question 1

Etoposide MOA

Answer 1

1) inhibit topoisomerase II

2) DNA strand breaks b/c no resealing of nicked strands

Question 2

Etoposide USES

Answer 2

broad spectrum

testicular carcinoma, lung, non-Hodgkin’s lymphoma

Question 3

Etoposide Toxicity

Answer 3

dose-limiting myelosuppression

oral mucositis

Question 4

Teniposide MOA & toxicity

Answer 4

same as etoposide

inhibit topoisomerase II

Question 5

Teniposide USES

Answer 5

ALL

Question 6

Irinotecan & Topotecan MOA

Answer 6

inhibit topoisomerase I

accumulation of ss DNA breaks

Question 7

Irinotecan USES

Answer 7

advanced colorectal cancer

lung, ovarian, cervical, brain tumors

Question 8

Topotecan USES

Answer 8

ovarian and small cell lung cancer

Question 9

Irinotecan & Topotecan toxicity

Answer 9

severe neutropenia

severe diarrhea