Microtubule Inhibitors

Question 1

Vinblastine MOA

Answer 1

M phase specific arrest, vinca alkaloid

1) bind to tubulin
2) block tubulin polymerization
3) arrest and death

Question 2

Vinblastine USES

Answer 2

testicular tumors (w/bleomycin & cisplatin)
ABVD for Hodgkin's disease

Question 3

Vinblastine Toxicity

Answer 3

myelosuppression, nausea, vomiting

Question 4

Vincristine MOA

Answer 4

M phase specific arrest, vinca alkaloid

1) bind tubulin
2) block tubulin polymerization
3) arrest and death

Question 5

Vincristine USES

Answer 5

child ALL (w/ glucocorticoids)
Hodgkin's & non-Hodgkin's lymphomas

Question 6

Vincristine Toxicity

Answer 6

dose-limiting neurotoxicity (peripheral neuropathy)

relatively low toxicity in bone marrow

Question 7

Paclitaxel MOA

Answer 7

taxane

1) bind to tubulin
2) BLOCK DEpolymerization/disassembly
3) no desegregation in mitosis

Question 8

Paclitaxel USES

Answer 8

metastatic breast/ovarian, lung, head/neck

Question 9

Paclitaxel Toxicity

Answer 9

peripheral neuropathy
hypersensitivity rxns (b/c from yew trees?)

Question 10

Docetaxel MOA

Answer 10

taxane

1) bind to tubulin
2) BLOCK DEpolymerization/disassembly
3) no desegregation in mitosis

Question 11

Docetaxel USES and toxicity

Answer 11

hormone refractory prostate cancer

and same as paclitaxel