Miscellaneous Agents

Question 1

Imatinib (Gleevac)

Answer 1

inhibitor of

1) abl kinase
2) PDGF-R
3) c-kit

for CML, gastrointestinal stromal tumor (GIST)

Question 2

Gefitinib (Iressa) & Erlotinib (Tarceva)

Answer 2

inhibit EDGF-R tyrosine kinase

for non-small cell lung cancer

Question 3

Hydroxyurea MOA

Answer 3

inhibits ribonucleoside diphosphate reductase

no deoxyribonucleotides for DNA

Question 4

Hydroxyurea USES

Answer 4

essential thrombocythemia
myeloproliferative neoplasmspolycythemia
sickle cell disease

Question 5

Retinoids (ATRA)

Answer 5

acute promyelocytic leukemia

remission in pts with APL

Question 6

Arsenic Trioxide

Answer 6

heavy metal toxin for relapsed APL

Question 7

Thalidomide

Answer 7

multiple myeloma and myelodysplastic syndromes

Question 8

Interferons

Answer 8

hairy cell leukemia
CML
Kaposi’s sarcoma

Question 9

Rituximab

Answer 9

monoclonal Ab

targets: CD20 B-cell antigen
for: non-Hodgkin’s lymphoma

Question 10

Trastuzumab (Herceptin)

Answer 10

monoclonal Ab
targets: HER2/neu (ErBB2)
For: Her2/neu overexpressing metastatic breast cancer

Question 11

Cetuximab

Answer 11

monoclonal Ab

targets: EGF-R1 (ErbB1)
for: EGF-R + metastatic colorectal cancer