Topoisomerase Inhibitor Flashcards
Etoposide (Etopophos) mechanism
Inhibits topoisomerase II
Etoposide (Etopophos) Therapeutics
Testicular carcinoma, lung cancer, and non-Hodgkin’s lymphoma
Etoposide (Etopophos) side effects
Dose-limiting myelosuppression(neutropenia), oral mucositis
Teniposide (Vumon) Mechanism
Inhibits topoisomerase II
Teniposide (Vumon) Therapeutics
ALL
Teniposide (Vumon) side effects
Dose-limiting myelosuppression(neutropenia), oral mucositis
Irinotecan (Camptosar) Mechanism
Inhibits topoisomerase I
Irinotecan (Camptosar) Therapeutics
Advanced colorectal cancer; lung,ovarian, cervical and brain tumors
Irinotecan (Camptosar) side effects
Severe neutropenia, severe diarrhea
Topotecan (Hycamtin) Mechanism
Inhibits topoisomerase I
Topotecan (Hycamtin) Therapeutics
Ovarian and small cell lung cancer
Topotecan (Hycamtin) side effects
Severe neutropenia, severe diarrhea
