Microtubule Inhibitors

Question 1

Microtubule Inhibitors

Answer 1

Inhibit mitosis and cause metaphase arrest by interfering with microtubule function (tubulin (de)polymerization); CCS

Question 2

Vinblastine (Velban) Mech

Answer 2

Block tubulin polymerization into microtubules

Question 3

Vinblastine (Velban) Therapeutics

Answer 3

Metastatic testicular tumors (with bleomycin, cisplatin); component ofABVD used for Hodgkin’s disease

Question 4

Vinblastine (Velban) side effects

Answer 4

Myelosuppression, nausea,vomiting

Question 5

Vincristine (Oncovin) Mech

Answer 5

Block tubulin polymerization intomicrotubules

Question 6

Vincristine (Oncovin) Therapeutics

Answer 6

Childhood ALL (with glucocorticoids);Hodgkin’s and non-Hodgkin’slymphomas

Question 7

Vincristine (Oncovin) side effects

Answer 7

Dose-limiting neurotoxicity(peripheral neuropathy). Relatively low bone marrow toxicity

Question 8

Paclitaxel (Taxol, Abraxane) Mech

Answer 8

Block microtubule depolymerization into tubulin

Question 9

Paclitaxel (Taxol, Abraxane) Therapeutics

Answer 9

Metastatic breast, ovarian, lung, and head and neck cancers

Question 10

Paclitaxel (Taxol, Abraxane) side effects

Answer 10

Peripheral neuropathy. Neutropenia; hypersensitivity reactions

Question 11

Docetaxel (Taxotere) Mech

Answer 11

Block microtubule depolymerization into tubulin

Question 12

Docetaxel (Taxotere) Therapeutics

Answer 12

Metastatic breast, ovarian, lung, and head and neck cancers; hormonerefractory prostate cancer

Question 13

Docetaxel (Taxotere) side effects

Answer 13

Peripheral neuropathy. Neutropenia; hypersensitivity reactions