Topo Inhibitors Flashcards
1
Q
Etoposide
A
Topo II inhibitor
Oral
Tox: N/V, hypotension, myelosuppression, ALOPECIA
2
Q
Topotecan
A
Topo I inhibitor
IV
Tox: N/V, ALOPECIA, neutropenia
Approved for SCLC
3
Q
Irinotecan
A
Prodrug, needs liver
Tox: SEVERE DIARRHEA, bone marrow suppression
First line drug for CRC