Taxanes

Question 1

General on taxanes

Answer 1

• Enhances microtubule polymerization
• Liver metabolism
• Solid tumors; BREAST, ovarian, NSCLC

Question 2

Paclitaxel

Answer 2

Tox: N/V, hypersensitivity, myelosuppression, NEUROTOX (peripheral neuropathy)

-albumin bound not immunogenic

Uses: breast, NSCLC, pancreatic

Question 3

Docetaxel

Answer 3

breast, NSCLC, head/neck cancers

Question 4

Ixebepilone

Answer 4

-microtubule inhibitor that is not a taxane but an Epothilone B agent

• binds and stabilizes beta tubulin
• active in tumors that express p-glycoproteins

Tox: myelosuppresison, hypersensitivity, neurotic

Use: breast cancer