Antitumor Antibiotics Flashcards
1
Q
Anthraclyclines
A
- inhibit topo II
- intercalator
- generate semi-quinone fre radicals (CARDIOTOX)
- binds to cell membranes
2
Q
Doxorubicin
A
IV
prodrug, needs liver
CARDIOTOX; acute arrhythmias, chronic cardiomyopathy myelosuppression, mucositis
Fe-chelator can reduce events in high risk its (dexrazoxane)
Wide efficacy, used as ABVDcombo therapy for Hodgkins
3
Q
Daunorubicin
A
AML
Ineffective with solid tumors
4
Q
Idarubicin
A
AML induction therapy combination with Ara-C
5
Q
Mitoxantrone
A
DNA strand breaker
Tox: ALOPECIA, BLUE SCLERA AND FINGERNAILS
6
Q
Mitomycin C
A
Requires reduction for activation, acts well on hypoxic tumors
alkylates, active in all phases of cell cycle
Tox: HUS!!!
7
Q
Bleomycin
A
Glycopeptide, binds DNA
Cell-cycle specific: G2 arrest
IV, IM, SQ —> renal
PULM TOX
Uses: testicular cancer, hodgkins/non
