Topical antibiotics Flashcards
What abx are bacteriostatic?
Chloramphenicol, clindamycin, Erythromycin, sulfonamides, tetracycline, trimethoprim
What is the mechanism of action of bacitracin?
INHIBITS bacterial cell wall synthesis;
Complexes with the carrier protein C55-prenol pyrophosphatase
What is the MOA of polymixin B?
Increases permeability of bacteria cell membrane by interacting w/ phospholipid components of membrane
Polymyxin B is most effective against what?
Gram negative organisms
What is the MOA of neomycin?
(an aminoglycoside) binds 30s subunit of ribosomal RNA
What is in triple antibiotic ointment?
Neomycin, Polymyxin B, Bacitracin
What is in neosporin?
Neomycin & polymyxin B
What is in polysporin?
bacitracin & polymyxin B
What is the MOA of Mupirocin?
Inhibits bacterial isoleucyl-tRNA synthetase - hinders bacterial RNA, protein, and cell wall synthesis
What is the MOA or retapamulin?
- Selectively inhibiting bacterial protein synthesis by interacting with the ribosomal protein L3 on the 50S ribosomal subunit
- Inhibiting ribosomal peptidyl transferase
- Preventing translation initiation by blocking interaction of fmet-tRNA to P-site of ribosome
What would you use in a mupirocin resistant MRSA?
retapamulin (altabax)
What is the MOA of genatmicin?
Irreversibly binds the 30s ribosomal subunit -Inhibits bacterial protein syntheis, mainly used in eye infections
What is the MOA of silver sulfadiazene?
Binds to bacteria DNA and inhibits its replication
Why is silver sulfadiazene so commonly in burn patients?
activity against pseudomonas
What is the MOA of sodium sulfacetamide?
inhibit bacterial synth of dihydrofolic acid by preventing condensation of pteridine precursors with PABA through inhibition of dihydropteroate synthetase
