Topic 8 Flashcards
What is the peripheral nervous system made up the
Sensory nerves
Motor nerves
Relay neurone
What is the peripheral nerves system divided into
Autonomic nervous system (involuntary)
Somatic nervous system
Voluntary stimulates skeletal muscles
What is the autonomic nervous system divided into
Sympathetic nervous system stimulated the body for fight or flight response ie increase heart rate
Parasympathetic nervous system
Prepares body for rest and digest
Distinguish between nerve and neurone
Neurone is single cell
Nerve is a group of neurones working together and
What are dendrites and axons
Dendrites- conduct impulses toward cell body
Axon transmit impulses away from cell body
What are the 3 types of neurone and state their function
Motor neurone they conduct impulses from the CNS to effectors
Sensory neurone- they carry impulses from sensory cells to CNS
Relay neurone- they are found in the CNS and they connect with other nerve cells
What the myelin sheath and what is it made from
They are around the axon and it’s a fatty insulating layer made up of Schwann cells
They enable the nerve impulses to happen faster
State the stages in the reflex arcs
A stimulus is detected by receptors and it generates a nerve impulse
Sensory neurones conducts a nerve impulse to the CNS
Sensory neurone enter the spinal cord through dorsal route
Synapse former between sensory and relay neurone
Relay neurone forms a synapse with motor neurone
Motor neurone carries impulses to an effector hormones which produces s response either bicep moving from flame
What controls the size of a pupil and state the two antagonistic muscles involved
Iris
Radial and circular muscles and these muscles are controlled autonomic nervous system
What controls the radial and circular muscles
Radial- sympathetic reflex
Circular muscles control parasympathetic reflex
State what each muscle is doing when the pupil constricts
Radial muscles relax
Circular muscles contract
State the role of each muscle when the pupil dilate
Radial muscles contract
Circular muscles relax
What is the resting potential of an axon and why is the membrane said to be polarised
-70mv
The inside of the axon is more negative than the outside
What is the role of the sodium potassium pump and how is it driven and what does it create
It’s role is to pump carry sodium out of the cell and potassium into the cell which creates polarisation
And it creates a concentration gradient and it driven by the energy from the hydrolysis of ATP
How was the resting potential of the an axon found
Experiments hodges placed two electrodes one in the bathing solution and one across the axon membrane and they found a potential difference of -70 mv
With the inside of the axon being more negative than the outside ( hence its polarised
Describe the process results in the resting potential of an axon to be -70 mv
The na/k pump creates a concentration gradient across the membrane
K plus diffuses out of the cell down the k concentration this action causes the outside of the memebrane to be more positive than the inside and it results in a potential difference being created as
The potential difference means some k ions willl be pulled back into the cell(some cl ions move out of the cell to balance the charge due to the pd )anions build up in the cell
When the pd across the membrane is around -70 mv the electrical and chemical gradient balance out and there no move movement of k
What is the chemical gradient and electrical gradient in resting potential
Chemical gradient is k going out via the pump
Electrical gradient- k being pulled in and cl going out
State the permeability of the membrane towards k and na ions
The membrane is permeable to potassium as it can go through a channel
It’s impregnable to sodium
What is depolarisation
This is when pd across the membrane is locally reversed with the outside of the axon now becoming negative and the inside being positive +40mv
What is repolarisation
When resting potential returns back to -70mv
What is action potential
The large change in voltage across the memebrane
What are the 3 stages in the generation of action potential
Depolarisation
Repolarisation
Restoring resting potential for
What are voltage dependant gated channels
They are channels that open as a result of changes in voltage across a membrane they block passage of na and k channels
What occurs in depolarisation
Due to stimulation The shape of the sodium gate changes shape due to change in PD across the membrane this opens some voltage dependant sodium ions channels
This causes na ions to flow inside the axon,meaning depolarisation increases which causes positive feed back meaning more sodium channel gates to open once a certain pd threshold is reached
This eventually leads to reverse in polarity meaning the PD across the memebrane reached +40 mv
What is meant by all or nothing
It means that actions potential either occur or not
What occurs in repolarisation
After 0.5ms the voltage dependant na channels close spontaneously
The voltage dependant k channels open meaning potassium ions move out of the axon by diffusion down an electrochemical gradient
As they flow outside of the cell the inside again becomes negative
How is resting potential restored
The voltage dependant k channels close and k ions begin to diffuse into the axon and it aids in restavlishing the rest potential
Furthermore the sodium potassium Pumps aids in restoring the original ion concentration across the CSM
What is hyperpolarisation
It is when the potential difference is more negative than the normal resting potential in a membrane
Describe each stage in transmission of action potential known as propagation
When stimulated the voltage dependant na+ channels open and this causes Na* ions to flow into the axon causing depolarisation of the memebrane and it causes localised electric currents to be generated
This in turn causes na+ ions to move to the adjacent polarised region and PD to changes across that part of the memebrane
The change in the potential difference in the membrane adjacent to the first action potential initates a second action potential at the site the first action potential the membrane because depolarised
The second action potential Iniates a 3rd action potential(electric currents cause nerve impulse move along the axon
What is meant by refractory period and what does this mean
A period after stimulation in which nerve impulse is unresponsive to further stimulation means action
Potential can’t be propagated backwards
What does refractory period mean for action potential direction
It means that it only goes in one direction as action potential can’t be generated in the same section
How long does refractory period last
Until resting potential is restored and na and k channels have returned ri their normal resting states
Where are the nodes of ranvier and what happens there
They occur at intervals in the myelin sheath and it’s where depolarisation takes place
What is the role of the myelin sheath
It acts as an electrical insulator and it prevents ions moving across the membrane
Describe the process of saltatory conduction
In depolarisation ions flow across the memebrane at one node,this sets up a circuit which reduces PD at the next node triggering an action potential
This result in a faster wave of depolarisation
What is meant by a synapse and synaptic cleft
Synapse is when two neurone meant
Synaptic cleft is the gap between them
Name the 3 main stages in synaptic action
Neurotransmitter release
Stimulation of post synaptic memebrane
Inactivation of neurotransmitters
Describe the process of neurotransmitter releases
An action potential depolarises a pre synaptic membrane and it increases its permeability to ca ions
There is a greater concentration outside the cell of ca ions and so Thei diffuse into the cytoplasm across the membrane
The increased ca ions cause the synaptic vesicles which contain acetylcholine to fuse with the pre synaptic membrane this causes them to release their contents by exocytosis into the synaptic cleft
Why are ca ions important in the release of a neurotransmitter
When they increase in concentration they cause synaptic vesicles to fuse and it results in them releasing their contents by exocytosis
Describe the process in stimulation of a post synaptic membrane
Acetylcholine molecule binds to a protein receptor on the post synaptic membrane causeing it to change shape
This makes it more permeable na ions the flow of na ions across the postsynaptic memebrane causes depolarisation and if it’s sufficient an action potential is produced which is propagated
Where are the nodes of ranvier and what happens there
They occur at intervals in the myelin sheath and it’s where depolarisation takes place
What is the role of the myelin sheath
It acts as an electrical insulator and it prevents ions moving across the membrane
What factors affect depolarisation of the post synaptic membrane
Depends on the amount of acetylcholine that reaches the post synaptic membrane
Functioning receptors on the post synaptic membrane
Why are na ions important in stimulation of the post synaptic membrane
It’s causes depolarisation of the post synaptic membrane meaning an action potential can occur