Topic 8 Flashcards

1
Q

Explain receptors and effectors

A

-Receptors detect stimuli, there are many types
-Receptors can be cells or proteins on cell surface membranes
-Receptors communicate to effectors by the nervous or hormonal system

-Effectors are cells that bring a response to a stimuli to produce an effect e.g muscle cells or glands

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2
Q

Explain the nervous system

A

-Sensory neurones - transmit E.I from receptors to CNS (brain and spinal cord)
-Relay neurones - transmit E.I between sensory and motor neurones
-Motor neurones - transmit E.I from CNS to effectors

-Stimulus: Dim light
-Receptors: light receptor detect this
-Information relayed across a sensory neurone
-Relay neurone passes it onto motor neurone from sensory
-Motor neurone passes information onto CNS which pass it to effectors to make a change
-Effectors contrart radial muscles to dilate/enlarge pupils

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3
Q

Explain hormonal system

A

-Hormonal system is made of glands and hormones
-Glands are a group of cells specialised to secrete useful substances e.g pancreas and insulin
-Hormones are chemical messengers
-When a gland is stimulated via a change in concentration of a substance or an E.I, hormones are secreted
-Hormones diffuse into the blood and are taken all over the body, diffusing anywhere
-Hormones can only bind to specific receptors on cell membranes known as target cells
-Hormones trigger a response in the target cells, the effectors

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4
Q

Explain difference of nervous and hormonal system

A

-Uses electrical impulses
-Faster response - E.I are rapid
-Localised response
-Short response

-Uses chemicals
-Slower response, hormones have to reach specific receptor
-Widespread response, hormones target cells all over the body
-Longer response, hormones break down slowly

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5
Q

Explain photoreceptors

A

-Light enters the eye through the pupil, amount is controlled by iris muscles

-Light rays absorb by photoreceptors in the retina
-Nerve impulses are carried from the retina to the brain by the optic nerve - a bundle of neurones
-Two types: Rod and Cones
-Rod receptors are found in the retina peripheral and gives information in black and white
-Cone cells are found packed together in the fovea (back of the eye) and gives information in colour

-They convert light to electrical impulses
-When absorbed, pigments are bleached causing a chemical charge
-This triggers a nerve impulse along a bipolar neurone which connects the photoreceptors to the optic nerve which sends information to the brain

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6
Q

Explain rod cells

A

-Type of photoreceptor which gives information in black and white
-Rod cells contain light-sensitive rhodopsin pigment
-Rhodopsin is made of retinal and opsin chemical joined together

-In the dark, your rods aren’t stimulated
-Na ions are pumped out of rod cell via active transport
-Na ions diffuse back in through open sodium channels
-This makes the inside slightly more negative then the outside, creating a depolarised membrane
-This triggers neutransmitter release which inhibit the bipolar neurone
-Bipolar neurone cannot fire an A.P to send information to the optic nerve thus to the brain

-In light, rod cells are stimulated
-Light energy breaks/bleaches rhodopsin into retinal and opsin
-Causing Na ion channels to close, preventing Na ions in and Na ions actively transporting out
-Na ions build up on outside, inside is much more negative - the cell membrane becomes hyperpolarised
-When the rod cell is hyperpolarised, neutransmitters release is inhibited preventing its inhibition of the bipolar neurone therefore an A.P is sent to the optic nerve and to the brain

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7
Q

Structure of Sensory neurone

A

-One long dendron that carries E.I to the cell body, in the middle of the neurone
-One short axon carries nerve impulse to the CNS

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8
Q

Structure of a Motor neurone

A

-Many short dendrites to carry E.I from CNS to cell body
-One long axon to carry E.I from cell body to effector cells

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9
Q

Structure of Relay neurone

A

-Many short dendrites to carry E.I from sensory neurone to the cell body
-Axon to carry nerve impulses from the cell body to motor neurones

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10
Q

Explain neurone cell membrane

A

-Polarised at rest, outside of a neurone’s membrane is more positively charged than the inside as more +ve ions are on the outside than inside
-Membrane is polarised, there is a difference in charge
-Voltage across the membrane at rest is the resting potential and its at -70mv

-Resting potential is created and controlled by sodium potassium pumps and potassium ion channel
-Sodium potassium pump moves 3Na ions out for every 2K ions in using ATP
-Na-K pump moves sodium ions out, and cannot diffuse back in due to membrane impermeable to Na whereas K ions can be pumped in and diffuse out via K channel
-This makes outside positively charged than inside

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11
Q

SAVE FOR LATER

A

page 179

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12
Q

Explain action potential effect on neurone

A

-When an A.P occurs, Na ions enter a neurone diffusing sideways causing sodium ion channels in the next region to open for Na ions to diffuse into that part.
-This creates a wave of depolarisation/A.P to travel along the neurone
-A.P moves away from parts of a membrane in the refratory period as they cannot fire an A.P

-Preventing movement of sodium ion channels stop A.Ps
-Local anaesthetics stop you feeling pain by binding to sodium ion channels to prevent sodium ions moving into neurones preventing depolarisation, preventing A.Ps from conducting and information of pain reaching the brain

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13
Q

Explain myelinated neurones

A

-Allows A.Ps to transmit faster
-Some neurones are myelinated which is an electrical conductor
-Made of schwann cells
-Between schwann cells are bare membrane named nodes of ranvier in which Na ion channels are concentrated
-In myelinated neurones, depolarisation only occurs at the nodes on ranvier, where Na ions can enter the membrane
-The neurone’s cytoplasm conducts enough charge to depolarise the next node so the impulse jumps from node to node named saltatory conduction which is rapid

-In non-myelinated neurones, the impulse travels as a wave through the axon membrane
-It is slower than saltatory conduction but is still quick

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14
Q

Explain synapses

A

-A synapse is a junction between a neurone and another cell e.g neurone of effector cell
-A tiny gap between the cells at a synapse is a synaptic cleft
-Presynaptic neurones (one before the synapse) has synaptic knob with synaptic vesicles filled with chemicals known as neurotransmitters
-When an A.P reaches the end of a neurone it causes synaptic vesicles to release into the synaptic cleft to diffuse to the postsynaptic membrane (one after the synapse) and bind to specific receptors
-When neurotransmitters bind to a receptor, they can trigger an A.P or muscle contraction or hormone secretion

-Receptors are only found on postsynaptic membranes, synapses make sure impulses are unidirectionaL
-Synapses allow information to be dispersed or amplified i.e one neurone connects to many or many neurones connect to one

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15
Q

Explain neurotransmitters – BETWEEN NEURONES

A

-Neurotransmitters transmit nerve impulses between neurones
-An A.P arrives at the presynaptic neurone which stimulates calcium ion gated channels to open
-Calcium ions then diffuse into the presynaptic knob
-Influx of calcium ions causes synaptic vesicles to move into the presynaptic membrane to be released into the synaptic cleft
-Neurotransmitters diffuse across the synaptic cleft to the specific receptors on the postsynaptic membrane
-This causes sodium ions on the postsynaptic membrane to open
-Na ions enter the postsynaptic membrane causing depolarisation

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16
Q

Explain plants response to stimuli

A

-Plants sense direction of light and grow towards it to maximise light absorbtion
-Plants sense gravity so they can shoot their roots and grow in the right direction (upwards)
-Climbing plants have a sense of touch to find things and reach for sunlight

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17
Q

Explain tropism

A

-Plants growth response to external stimuli
-Tropism is the response of a plant to a directional stimuli and respond by regulating growth
-Positive tropism is to the stimuli, negative is away from the stimuli

18
Q

Explain growth factors / auxin

A

-Plants have no nervous or hormonal system, they respond using growth factors which speed or slow down plant growth
-Growth factors are producing in growing regions of the plant and move to where they are needed
-Growth factors are named auxins and stimulate growth of shoots by cell elongation (cells become loose and stretchy)
-High auxin concentration inhibits growth
-Other plant factors such as cytokinins which stimulate cell division and differentiation
-IAA is main auxin

19
Q

Explain IAA

A

-Type of auxin produced in tips of shoot in flowering plants
-When it enters nucleus of cell, it regulates transcription of genes related to cell elongation
-It moves by diffusion and active transport over short distances and via phloem over longer
-This results in an uneven distribution resulting in uneven growth

20
Q

Explain photoreceptors

A

-Photoreceptors called phytochromes detect light, found in many plant parts e.g leave, seet, root
-Phytochromes control many responses
-Phytochromes are molecules that absorb light, exist in 2states, Pr and Pfr which absord light at 660nm and 730nm respectively
-Phytochromes change state when exposed to different light concentrations
-Pr quickly converts to Pfr in red light
-Pfr quickly converts to Pr when exposed to FR light (or slowly when in darkness)
-Daylight contains more Fr so more Pr converted to Pfr than vice versa
-Differing amount of phytochrome types regulate transcription of genes
-High Pfr levels stimulate flowering

21
Q

Explain the cerebrum and cerebellum

A

-Largest part of the brain, divides into right and left cerebral hemisphere
-Cerebrum is involved in vision, learning, thinking, emotions and movement
-Back is involved in vision, front is involved in thinking

-Cerebellum is underneath the cerebrum
-Important for coordinating movement and balance

22
Q

Explain the hypothalamus

A

-Found just beneath the middle part of the brain
-Automatically maintains body temperature - thermoregulation
-Produes hormones that controls the pituitary gland below it

23
Q

Explain the medulla oblongata

A

-Located at the base of the brain and top of spinal cord
-Controls breathing rate and heart rate

-Inspiratory & expiratory centre
-Cardiac Control Centre

24
Q

Explain CT scanning

A

-Uses lots of x-rays (radiation)
-Shows major brain structures but now the functions
-Medical diagnostics can be aided with this
-Shows if a brain is diseased or damaged which can be used to determine function
-If an area of a brain is damaged and the patient reports vision loss, that area might be faulty
-Blood has a differing density than brain tissue, so it’ll show up lighter - extent of bleeding can be seen which can allow for knowing what vessel is damaged

25
Q

Explain MRI scanning

A

-Magnetic resonance imaging
-Uses magnetic fields and radio waves to produce cross sectional images of the brain
-Produces high quality images and better resolution allowing to easily compare a brain to another

-MRI can be used to diagnose medical issues as it shows damaged or diseased areas of the brain
-Tumour cells respond differently, they show up lighter than healthy cells
-Exact size of a tumour can be seen and its location too

26
Q

Explain fMRI scanning

A

-Functional magnetic resonance imaging
-Provides detailed high resolution picture of the brain
-If a patient does an action, the image will show part of the brain highlighted that is involved in carrying out the action

-fMRI can be used to show damaged or diseased areas
-Allows for studying of diseased area
-fMRI can be taken on a patient’s brain before and during a seizure to find the part of the brain operating incorrectly

27
Q

Explain PET scanning

A

-PET scans can show how active different areas of the brain are
-A radioactive tracer is put into the body in which tissues absort it
-Scanner than detects radioactivity which can help build a map/image
-PET scans produce detailed imaging and can be used to research brain structure and function in real time
-PET scans usually show if parts of the brain as unusually active or inactive so can be used to diagnose alzheimers where metabolism in the brain is reduced

28
Q

Explain habituation

A

-Animals increase chances of survival by responding to stimuli
-If a stimuli is constant is is unimportant, the animal will learn to ignore it over time, this is habituation
-Habituation means energy isnt wasted responding to unimportant thing

-Gently brush a blade of grass across the surface of a snails skin close to tentacles, this will cause the snail to withdraw into its head
-Using a stopwatch, measure the time taken for the snail to exit it’s head
-Repeat this at regular intervals
-Habituation can be seen in the snail as it should emerge out of its head quicker every time - after some time the snail may just ignore the stimuli and not withdraw into its head

29
Q

Explain visual cortex

A

-Area of the cerebral at the back of the brain
-Visual cortex recieves and processes visual information via neurones in your eyes
-Neurones group together forming the ocular dominance columns, there is a left and right one
-Columns are the same size and alternate between the two, across the visual corex

30
Q

Explain how animal models are used to study visual cortex

A

-Animals used instead as it is more unethical to test on humans
-Done by Hubel and Wiesel, studying elecrical activity of neurones in the visual cortex
-One of a kitten’s eye was stiched shut, and this remained for many months
-After removal of stiches, the kitten was investigated and the kitten’s stiched eye was blind
-The ocular dominance columns were also smaller and the healthy eye’s ocular dominance columns was larger than usual as they expanded to take over other unstimulated columns

-This was tested on an adult cat and the cat regained eyesight shortly
-This was also tested on monkeys and the results were the same as the kittens

-This provides evidence for a “critical period” in humans

31
Q

Explain the critical period

A

-Hubel and wiesel’s investigation proves a period in early life where exposure to visual stimuli is required to develop the visual cortex
-Visual stimulation organises the neurons (ocular dominance columns)

-During critical period, synapses recieve visual information and pass nerve impulses into the visual cortex
-Synapses that don’t recieve information don’t pass on nerve impulses into the visual cortex are removed
-This means without proper stimulation of visual information, the visual cortex will not develop and synapses will be destroyed

32
Q

Explain how use of animals in medical research raises ethical questions

A

-Animals are different from humans, they may have differing reactions
-Animals can feel pain and distress
-Alternatives such as human cells or modelling technology

-Animals are similar to humans hence many medical breakthroughs have been made
-Animal experimentations should only be done is necessary and guidelines must be followed
-Using animals correctly is the only way to find out all side effects
-Humans have a greater right to life as we have more complex brains

33
Q

Explain investigating nature/nurture through twin studies

A

-Identical twins are raised seperately, exposing them to differing enviroments
-Scientists can then compare brain development of the twins and note any differences and if its due to nature or nurture
-Such as identical twins have similar IQ scores indicates nature plays a huge role in this
-However twins shared the same enviroment in the womb so enviroment was not completely regulated
-Identical twins can be compared to non identical twins, they act as the control
-Stuttering of both identical twins is more common than in non identical suggesting nature plays a bigger role in developing speech
-Reading ability is the same between both twins suggesting nurture affects that area

34
Q

Explain investigating nature/nurture through cross cultural studies

A

-Children brought up in differing cultures face differing enviroments e.g beliefs and education
-Scientists can studdy the effects of upbringing on braind evelopment by comparing large groips of children of the same age from differing cultures
-Major characteristics that differ can be noted and any differences are more likely to be nurture
-Similarities in brain development are more likely to be nature e.g mapping abilities are well developed across the differing children.

35
Q

Explain investigating nature/nurture through newborn and brain damage studies

A

-Brain of a newborn has not been developed and enviromentally affected
-Scientists can study newborns to see the functions they are born with and how developed the brain is
-This is more likely to be nature than nurture

-Damage to an adults brain can lead to loss of brain function eg stroke causing vision loss
-An adults damaged brain cannot repair itself as the brain had fully developed unlike a childs
-Scientists can compare brain development of children with and without brain damage
-If a characteristic develops in both, it is more likely to be nurture
-If a characteristic develops in children with brain damage, it is more likely to be nature

36
Q

Explain parkingsons disease

A

-Parkingsons disease is a brain disorder that affects people’s movement ability
-The neurones in parts of the brain that control movement are destroyed
-These normally produce dopamine - there is now a reduction in dopamine
-Less Dopamine will be released into the synaptic cleft meaning less bind to receptors on the postsynaptic membrane
-Fewer Na channels open so the depolarisation threshold is harder to meet
-This leads to tremors and slow movement
-L-Dopa is a drug used to increase level of dopamine in the brain

37
Q

Explain depression

A

-There may be a link between serotonin neurotransmitter and depression
-Serotonin transmists nerve impulses across parts of the brain controlling mood
-Drugs such as antidepressants increase levels of serotonin in the brain
-Some drugs are used which increase serotonin levels by preventing is reuptake at synapses

38
Q

Explain L-Dopa

A

-Drug used to treat parkingsons disease
-L-Dopa is to be absorbed into the brain and converted into dopamine by the enzyme dopa-decarboxylase
-This is to increase levels of dopamine which ensures more nerve impulses are transmitted across parts of the brain controlling movement
-The sufferes should be able to have more control of their movements

39
Q

Explain MDMA (ecstasy)

A

-Drug used to treat depression by increasing levels of serotonin in the brain
-Usually serotonin is to be taken back into the presynaptic neurone, after triggering an A.P, to be used again
-MDMA works by inhibiting the reuptake of serotonin into the presynaptic neurone by binding to and blocking the reuptake proteins
-MDMA also triggers the release of serotonin from presynaptic membrane, this keeps the levels high to cause depolarisation of the postsynaptic neurones in parts of the brain controlling mood

40
Q

Explain genetically modified microorganisms

A

-Gene for protein is isolated using restriction endonuclease
-Gene is copied via PCR reaction
-Copies are inserted into plasmids which are transferred into microorganisms
-Modified microorganism is then grown in large to produce lots of the useful protein
-Protein can be purified and used as a drug

41
Q

Explain genetically modified microogranisms

A

-Gene for the drug is inserted into a bacterium
-Bacterium infects a plant cell
-Bacterium inserts gene into plant cell DNA - Plant is now genetically modified
-Plant cell grows into adult plant and the whole plant now have a copy of every gene
-Drug produced can be purified from plant tissue and used