Topic 6: Parentage

Question 1

What is an exclusion analysis?

Answer 1

Given the offspring genotype, and the genotype of a known parent (mother), exclude all individuals if they do not carry the required parental allele, and that single non-excluded parent must be the dad

Question 2

What is the next step after exclusion analysis if there if more than one individual who has not been excluded?

Answer 2

You perform an inclusive likelihood analysis that calculates the probability of the offsprings observed genotype given the possible parents. The individual with
highest likelihood is considered the parent

Question 3

What is the probability of exclusion?

Answer 3

The significance of a paternity analysis is judged by the probability that a random individual will be excluded of being the father.

Question 4

What is the probability of exclusion at one locus for a given offspring when you know which allele must have been paternally derived?

Answer 4

Pex = (1-a)^2
Where a is the paternally derived allele

Question 5

What is the probability of exclusion at one locus for a given offspring when either allele could have come from the father (both mom and dad are heterozygotes)?

Answer 5

Pex= (1-a-b)^2

Question 6

What is the probability of inclusion at multiple loci?

Answer 6

The product of (1-Pex) at all loci

Question 7

What is the probability of exclusion at multiple loci?

Answer 7

1-Pinc