Topic 6 Flashcards
What is homeostasis
involves using physiological systems to maintain a constant internal environment within fixed limits
Why is maintaining a stable internal temperature and PH important
To ensure that the enzymes involved in metabolic reactions are operating at the optimal temperatures
What is negative feedback
Used in homeostasis
If the stimulus is above the limits ,then the body will work to reduce it and vice versa
When does blood glucose levels rise
After a carbohydrate containing meal
What are the two hormone involved in maintaining blood glucose
Insulin
Glucagon
What is the main organ involved in maintaining blood glucose levels
Pancreas
What is the area of the pancreas where cells secrete insulin
Islets of langerhan
What are the two types of cells which secrete hormones
Beta cells secrete insulin
Alpha cells secrete glucagon
What happens when blood glucose levels are too high
- Pancreas detects the rise in blood glucose
- a cells stop secreting glucagon and b cells start secreting insulin
- Insulin binds to receptors on liver and muscle cells
- Muscle cells are stimulated to take up more glucose
- Liver cells are stimulated to take up glucose and initiate glycogenosis
- Blood glucose levels drop down
What happmes when blood glucose is too low
- The pancreas detects a drop in blood glucose
- a cells start secreting glucagon and b cells stop secreting insulin
3.Glucagon binds to receptors on liver cells - This activates glycogenolysis
- Liver cells release glucose into the blood
- Blood glucose levels return to normal
Define glycogenesis
The process of excess glucose being converted to glycogen when blood glucose is too high
Define glycogenolysis
1.The hydrolysis of glycogen back into glucose in the liver
- Occurs when blood glucose levels are lower than usual
Gluconeogenesis
- Process of creating glucose from noncarbohydrate stores in the liver
- This occurs if all glycogen has been hydrolysed into glucose and your body still needs more glucose
What organ regulates water potential
The kidneys
How does the kidneys regulate water potential
In the kidneys, water is filtered out of the blood and then reabsorbed so that the water potential of blood can be controlled
Where in the kidneys is water filtered
In the nephron
Where is the nephron located
Found in the cortex and medulla layers of the kidney
What is the hormone for the regulation of blood glucose
The hormone ADH is used in the regulation of blood glucose
Where is ADH secreted
It is secreted by the posterior pituitary gland in the brain
What is the role of ADH
It controls how permeable the distal convoluted tubule (DCT) and collecting duct is to water which changes the amount of water that is reabsorbed
What happens if blood water potential is too high
1.Osmoreceptors in the hypothalamus detect the rise in water potential
2.The posterior pituitary gland releases less ADH into the blood
3.Less ADH results in the DCT and collecting duct becoming less permeable to water so less water is reabsorbed
4.This results in a larger amount of more dilute urine being produced
What happens if blood water potential is too low
1.Osmoreceptors in the hypothalamus detect the drop in water potential
2.The posterior pituitary gland releases more ADH into the blood
3.More ADH results in the DCT and collecting duct becoming more permeable to water so more water is reabsorbed
4.This results in a smaller amount of more concentrated urine being produced
How are nerve impulses transmitted
Via neurons
What are three types of neurons
Motor
Sensory
Relay
What is the role of sensory neurone
Sensory neurons transmit impulses from receptors to the CNS
Give two ways person with type 1 diabetes controls blood glucose
Treat with insulin
Control diet
Role of all three neurons
Sensory : transmits information from receptors to CNS
relay: transmits signals from sensory to motor
Motor : transmits impulses from CNS to an effector
When a neurone is at rest is the inside of cell membrane negative or positive
Negative
What is the resting potential
-70 mv
How is resting potential maintained
By sodium -potassium pumps
Describe the process in how resting potential is maintained
Sodium-potassium pumps move sodium out of the neuron and potassium into the neurone
The cell membrane is permeable to potassium but not sodium, so the potassium inside the neuron moves out down its concentration gradient
This means that overall there are more positive charges on the outside of the cell than on the inside which results in the inside being more negative than the outside
How does depolarisation occur
When a neuron is stimulated, Na+ voltage-gated channels open so Na+ ions move into the membrane, depolarizing it
How does an action potential occur
this depolarization reaches the threshold potential of about -55mV, it is the beginning of an action potential
Describe repolarisation
Na+ voltage-gated channels then close and K+ voltage-gated channels open, repolarising the membrane
What is the threshold value
-55mV