Topic 4.3: Blood and Immunity Flashcards
Which of the following allows rapid change in one direction but does not achieve stability?
a) homeostasis
b) positive feedback
c) negative feedback
d) all of the above
b) positive feedback
Which of the following is an example of negative feedback?
a) uterine contractions increase as labor progresses
b) insulin decreases blood sugar levels after a meal is eaten
c) sweating increases as body temperature drops
d) platelets continue to plug an opening in a blood vessel until blood flow stops.
b) insulin decreases blood sugar levels after a meal is eaten
Which of the following is not a function of blood?
a) regulation of the body temperature
b) defense of the body
c) transport of oxygen and carbon dioxide
d) manufacture of hormones
d) manufacture of hormones
Which of the following is/are formed from megakaryocytes?
a) basophils
b) platelets
c) erythrocytes
d) fibrinogen
b) platelets
Which of the following is not a white blood cell?
a) lymphocyte
b) neutrophil
c) eosinophil
d) basophil
e) all of the above
e) all of the above
Summarize the three functions of the lymphatic system.
Excess interstitial fluid moves into the lymph vessels and is returned to the blood stream.
Fats from the small intestine move into the lymph vessels and are transported into the bloodstream.
White blood cells in the lymph system function in protecting the body from disease.
Explain how lymph is different than blood.
Lymph is the excess interstitial fluid that has been absorbed into the lymphatic vessels. It is mostly water but also contains nutrients, electrolytes, oxygen, hormones, enzymes, and wastes. Blood contains erythrocytes, leukocytes, platelets, waste solutes, and products of cells.
Distinguish between the function of a primary and secondary lymphoid organ
In the red bone marrow and the thymus, which are primary lymphoid organs, lymphocytes develop and mature. In the secondary lymph organs, such as the lymph nodes and the spleen, lymphocytes become activated.
Define lymphatic system
Organ system consisting of lymphatic vessels and lymphatic organs; transports lymph and lipids, and aids the immune system.
Define lymphatic vessels
Vessel of the lymphatic system that is responsible for transporting excess interstitial fluid, or lymph, from the tissues to the circulatory system.
Define lymphatic capillary
Smallest vessels of the lymphatic system; closed-ended; responsible for the uptake of fluids from the surrounding tissues.
Define lymph
Fluid, derived from interstitial fluid, that is carried in lymphatic vessels.
Define lymphoid organ
Organ other than a lymphatic vessel that is part of the lymphatic system; the lymphatic organs are the lymph nodes, tonsils, spleen, thymus gland, and bone marrow.
Define lymphocyte
Specialized white blood cell that functions in specific defense; occurs in two forms—T lymphocytes and B lymphocytes.
Define red bone marrow
Vascularized, modified connective tissue that is sometimes found in the cavities of spongy bone; site of blood cell formation.
Define thymus
Lymphoid organ involved in the development and functioning of the immune system; T lymphocytes mature in the thymus.
Define spleen
Large, glandular organ located in the upper left region of the abdomen; stores and filters blood.
Define lymph nodes
Mass of lymphatic tissue located along the course of a lymphatic vessel.
Define pathogen
Disease-causing agent such as viruses, parasitic bacteria, fungi, and animals.
Name on physical and one chemical barrier to infection.
The skin and mucous membranes are physical barriers; a chemical barrier is the acid of the stomach.
Summarize the stages of an inflammatory response.
- Injured tissue cells and mast cells release histamine and other chemical mediators, which cause capillaries to dilate and increase blood flow.
- Resident macrophages and dendritic cells phagocytize pathogens and release cytokines, which stimulate the inflammatory response.
- Neutrophils and monocytes (become macrophages) squeeze through the capillary wall and phagocytize pathogens.
- Blood clotting walls off capillary and prevents blood loss.
Contrast the way that macrophages typically kill pathogens with the method used by natural killer cells.
Macrophages kill pathogens by engulfing them into a vesicle that has an acid pH, hydrolytic enzymes, and reactive oxygen compounds.
NK cells induce cells that lack self-MHC-I molecules to undergo apoptosis (cell suicide).
Summarize three major functions of the complement system
The complement system enhances phagocytosis of pathogens, activates inflammation, and kills pathogens by forming a membrane attack complex.
Define immune system
System associated with protection against pathogens, toxins, and some cancerous cells. In humans, this is an organ system.
Define immunity
Ability of the body to protect itself from foreign substances and cells, including disease-causing agents.
Define innate immunity
An immune response that does not require a previous exposure to the pathogen.
Define adaptive immunity
Type of immunity that is characterized by the response of lymphocytes to specific antigens.
Define inflammatory response
Tissue response to injury that is characterized by redness, swelling, pain, and heat.
Define mast cells
Connective tissue cell that releases histamine in allergic reactions.
Define histamine
Substance, produced by basophils in blood and mast cells in connective tissue, that causes capillaries to dilate.
Define macrophages
In vertebrates, large phagocytic cell derived from a monocyte, that ingests microbes and debris.
Define dendritic cells
Antigen-presenting cell of the epidermis and mucous membranes.
Define cytokines
Type of protein secreted by a T lymphocyte that attacks viruses, virally infected cells, and cancer cells.
Define phagocytes
Type of white blood cells that destroy pathogens using phagocytosis.
Define neutrophils
Granular leukocyte that is the most abundant of the white blood cells; first to respond to infection.
Define monocyte
Type of agranular leukocyte that functions as a phagocyte, particularly after it becomes a macrophage, which is also an antigen-presenting cell.
Define natural killer (NK) cells
Lymphocyte that causes an infected or cancerous cell to burst.
Define complement system
Collective name for a series of proteins in the blood, some of which act as enzymes and activators, which bind to antibodies and may lead to rupture of a foreign cell.
Define interferons
Antiviral agent, produced by an infected cell, that blocks the infection of another cell.
Describe 4 mechanisms that result in the generation of antigen receptor diversity .
Diversity in antigen receptors occurs because:
- Genes for T- and B-cell receptors contain segments that code for many parts of the antigen receptor.
- Enzymes in the T and B cells cut out these segments and combine them differently.
- Mutations may be introduced as these segments are combined.
- The two protein chains, containing the variation of steps 1-3 combine to produce a new receptor.
Discuss the major tenets (principles) of the clonal selection theory.
The clonal selection theory states that B cells and T cells have cell surface receptors for only one specific antigen. When the cell contacts that specific antigen, it is selected to undergo clonal expansion (divide) and differentiate into either memory cells or cells that actively fight infection.
List the five classes of human antibodies and their main functions.
IgG: Activates complement, crosses the placenta
IgM: Early response, activates compliment
IgA: protects respiratory tract
IgD: activates B cells
IgE: protects against parasites
Contrast the specific functions of helper T cells, suppressor T cells, and cytotoxic T cells.
Helper T cells recognize antigen fragments in combination with MCH molecules presented by antigen-presenting cells that have MHC class II proteins on their surface.
Cytotoxic T cells recognize antigen -presenting cells with MHC class I proteins.
Suppressor T cells inhibit these responses and act to control adaptive immunity.
Define antigen
Foreign substance, usually a protein or a polysaccharide, that stimulates the immune system to react, such as to produce antibodies.
Define clonal selection
States that the antigen selects which lymphocyte will undergo clonal expansion and produce more lymphocytes bearing the same type of receptor.
Define plasma cell
Mature B cell that mass-produces antibodies.
Define B-cell receptor (BCR)
Molecule on the surface of a B cell that binds to a specific antigen.
Define antibody
Protein produced in response to the presence of an antigen; each antibody combines with a specific antigen.
Define memory B cell
Forms during a primary immune response but enters a resting phase until a secondary immune response occurs.
Define antibody-mediate immunity
Specific mechanism of defense in which plasma cells derived from B cells produce antibodies that combine with antigens.
Define immunoglobulin (Igs)
Globular plasma protein that functions as an antibody
T-cell receptor (TCR)
Molecule on the surface of a T cell that can bind to a specific antigen fragment in combination with an MHC molecule.
MHC (major histocompatibility complex) protein
Protein marker that is a part of cell-surface markers anchored in the plasma membrane, which the immune system uses to identify “self.”
Define helper T cells
Secretes lymphokines, which stimulate all kinds of immune cells.
Define cytotoxic T cell
T lymphocyte that attacks and kills antigen-bearing cells.
Define antigen-presenting cells (APC)
Cell that displays an antigen to certain cells of the immune system so they can defend the body against that particular antigen.
Define memory T cells
T cell that differentiates during an initial infection and responds rapidly during subsequent exposure to the same antigen.
Define cell-mediated immunity
Specific mechanism of defense in which T cells destroy antigen-bearing cells.