topic 3 Flashcards

1
Q

How do pathogens affect the body?

A

Microorganisms that enter body and cause disease, cause communicable disease-disease that can easily spread, both plants and animals can be infected by pathogens.

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2
Q

What are bacteria?

A

very small cells (about 1/100th size of body cells) which can reproduce rapidly inside your body. Can make you feel ill by producing toxins (poisons) that damage your cells and tissues.

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3
Q

What are viruses?

A

Not cells, are tiny about 1/100th size of bacterium, like bacteria, can reproduce rapidly inside body. Live in cells and replicate themselves using cells’ machinery to produce many copies of themselves. Cell will usually then burst, releasing all new viruses, cell damage is what makes you feel ill.

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4
Q

What are protists?

A

Lots of different types of protists. But all eukaryotes, most are single-celled. Some protists are parasites. Parasites live on or inside other organisms and can cause them damage-e.g.an insect that carries the protist.

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5
Q

What is fungi?

A

Some are single-celled. Others have body which is made up of hyphae (thread-like structure). These hyphae can grow and penetrate human skin and surface of plants causing, disease. Hyphae can produce spores, which can be spread to other plants and animals.

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6
Q

How can pathogens be spread through water?

A

some pathogens can be picked up by drinking or bathing in dirty water. E.g. cholera is a bacterial infection that’s spread by drinking water contaminated with diarrhoea of other sufferers.

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7
Q

How can pathogens be spread through air?

A

Pathogens can be carried in air and can then be breathed in . Some airborne pathogens are carried in air in droplets produced when cough or sneeze-e.g the influenza virus that cases flu is spread this way.

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8
Q

How can pathogens be spread through direct contact?

A

Some pathogens can be picked up by toughing contaminated surfaces, including skin. E.g. athlete’s foot is a fungus which makes skin itch and flake off. Most commonly spread by touching same things as an infected person, e.g. shower floors and towels.

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9
Q

What is measles, what are symptoms and how is it treated?

A

is viral disease. Spreads by droplets from infected person’s sneeze or cough, people with measles develop a red skin rash, and they’ll show signs of a fever (high temperature). Measles can be very serious, or even fatal, if are complication. E.g. measles can sometimes lead to pneumonia (lung infection) or brain infection called encephalitis. Most people are vaccinated against measles when young.

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10
Q

What is HIV, what are the symptoms and how is it treated?

A

Is virus spread by sexual contact, or by exchanging bodily fluids such as blood. Can happen when people share needles when taking drugs. HIV initially causes flu-like symptoms for a few weeks. Usually, person doesn’t then experience any symptoms for several years. During this time, HIV can be controlled with antiretroviral drugs. These stop virus replicating in body. Virus can attack immune cells. If body’s immune system is badly damaged, can’t cope with other infections or cancers. At stage, virus is knows as late stage HIV infection.

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11
Q

What is tobacco mosaic virus (TMV), what are symptoms and how can it be treated?

A

is virus that affects species of plants e.g. tomatoes. Causes mosaic pattern on leaves of plant-parts of leaves become discoloured. Discolouration means plant can’t carry out photosynthesis as well, so virus affects growth.

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12
Q

What is rose black spot?

A

is fungus, causes purple or black spots to develop on leaves or rose plants. Leaves can turn yellow and drop off. Means less photosynthesis can happen, so plant doesn’t grow very well. Spreads through environment in water or by wind. Gardeners can treat disease using fungicides and by stripping plant of its affected leaves. These leaves then need to be destroyed so fungus can’t spread to other rose plants.

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13
Q

What is malaria?

A

Caused by protist. Part of malaria protist’s life cycle takes place inside mosquito. These mosquitoes are vectors-pick up malarial protsit when feed on infected animal. Every time mosquito feeds on another animal, infects by inserting protist into animal’s blood vessels. Malaria causes repeating episodes of fever. Can be fatal. Spread of malaria can be reduced by stopping mosquitoes from breeding. People can be protected form mosquitoes using insecticides and mosquito nets.

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14
Q

What is salmonella-type of bacteria that causes food poisoning?

A

Infected people can suffer from fever, stomach cramps, vomiting and diarrhoea. Symptoms caused by toxins that bacteria produce. Can get salmonella food poisoning by eating food that’s contaminated with Salmonella bacteria e.g. eating chicken that caught disease whilst alive, or unhyginically preparing food and consuming it.

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15
Q

Is there a a vaccination for Salmonella?

A

Most poultry (e.g. chickens) given vaccination against Salmonella. To control spread of disease.

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16
Q

What is gonorrhoea-STD?

A

Passed on by sexual contact. Caused by bacteria. Person with gonorrhoea will get pain when urinate. Other symptom is thick yellow discharge from vagina on penis. Gonorrhoea was originally treated with antibiotic called penicillin, but has become trickier now because strains of bacteria have become resistant to it.

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17
Q

How do you treat gonorrhoea?

A

With antibiotics and should use barrier methods of contraception e.g. condoms.

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18
Q

How can being hygienic prevent spread of disease?

A

Using simple hygiene methods can prevent spread of disease. e.g. washing hands thoroughly before preparing food of after sneezed can stop infecting others.

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19
Q

How can destroying vectors prevent spread of disease?

A

By getting rid of organisms that spread disease, can prevent disease from being passed on. Vectors that are insects can be killed using insecticides or by destroying their habitat so that can no longer breed.

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20
Q

How can isolating infected individuals prevent spread of disease?

A

If isolate someone who has communicable disease, it prevents them from passing it on to anyone else.

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21
Q

How can vaccination prevent the spread of disease?

A

Vaccinating people or animals against communicable diseases means, can’t develop infection an then pass it on to someone else.

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22
Q

What are examples of the body’s defence system?

A

Skin acts as barrier to pathogens. Also secrets antimicrobial substances which kills pathogens. Hairs and mucus in nose trap particles that could contain pathogens. Trachea and bronchi secrete mucus to trap pathogens. Trachea and bronchi are lined with cilia. These hair-like substances, which waft mucus up to back of throat where it can be swallowed. Stomach produces hydrochloric acid. This kills pathogens that make it that far from mouth.

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23
Q

How can your immune system attack pathogens?

A

Most important part of immune system is white blood cells. They travel around in blood and crawl into every part of body, constantly patrolling for microbes. When come across invading microbe, they have 3 lines of attack.

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24
Q

How do white blood cells consume pathogens?

A

Engulf foreign cells and digest them. Called phagocytosis.

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25
Q

How do white blood cells produce antibodies to attack pathogens?

A

When some types of white blood cell come across foreign antigen, will start to produce proteins called antibodies to lock onto invading cells so can be found and destroyed by other white blood cells. Antibodies produces are specific so that type antigen-won’t lock into others’ unique molecule on surface.

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26
Q

How do antibodies attack pathogen?

A

Antibodies are produced rapidly and carried around body to find similar bacteria or viruses. If person is infected with same pathogen again white blood cells will rapidly produce antibodies to kill it-person naturally immune to pathogen and won’t get ill. See revision guide.

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27
Q

How do white blood cells produce antitoxins to attack pathogens?

A

These counteract toxins produced by invading pathogen.

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28
Q

How long does it take for a pathogen to know what to do with a pathogen?

A

A few days.

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29
Q

What is a vaccination?

A

Involve injecting small amounts of dead or inactive pathogens. Carry antigens which cause body to produce antibodies to attack them-even though pathogen is harmless. E.g. MMR vaccine contains weakened version of viruses that cause measles, mumps and rubella all in 1 vaccine.

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30
Q

What happens if live pathogens of the same type appear in the bloodstream?

A

White blood cells can rapidly mass-produce antibodies to kill of pathogen.

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31
Q

What are the positives of vaccinations?

A

Helped control lots of communicable diseases that were once common in UK (e.g. polio). Smallpox no longer occurs at all, and polio infects have fallen 99%. Big outbreaks of disease-epidemics can be prevented if large percentage of population vaccinated. That way, even people who aren’t vaccinated are unlikely to catch disease because fewer people able to pass it on. But if significant number of people aren’t vaccinated, disease can spread quickly through them and lots of people will be ill at same time.

32
Q

What is heard immunity?

A

the resistance to the spread of a contagious disease within a population that results if a sufficiently high proportion of individuals are immune to the disease, especially through vaccination.

33
Q

What are negatives to vaccines?

A

Don’t always work-sometimes don’t give immunity. Can sometimes have bad reaction to vaccine (e.g. swelling). But bad reaction are rare.

34
Q

What are painkillers?

A

Drugs that relieve pain. However, don’t actually tackle cause of disease or kill pathogen, just help to reduce symptoms. Other drugs can do similar thing-reduce symptoms without tackling underlying cause. E.g. lost of “cold remedies” don’t actually cure colds.

35
Q

What are antibiotics?

A

Kill bacteria causing problem without killing body cells. Different antibiotics kill different bacteria, so important to be treated with right one. Don’t destroy viruses. Viruses reproduce using body cells which makes it very difficult to develop drugs that destroy just virus without killing body cells. Use of antibiotics has greatly reduced number of deaths from communicable diseases caused by bacteria.

36
Q

What does bacteria mutating mean?

A

sometimes mutations cause bacteria to be resistant to antibiotic. If no infection, some of bacteria might be resistant to antibiotics. Means that when treat infection, only non-resistant strains of bacteria will be killed.

37
Q

What can an individual resistance of bacteria cause?

A

Cause bacteria to survive and reproduce, and population of resistant strain will increase. Resistant strain could cause serious infection that can’t be treated by antibiotics. E.g MRSA causes serious would infections and is resistant to powerful antibiotic meticillin.

38
Q

How do you slow the rate of development of resistant strains?

A

Doctors to stop over-prescribing antibiotics. So won’t get them for a sore throat, only for something more serious. Also important that finish whole course of antibiotics and don’t just stop once feel better.

39
Q

what do plants provide for drugs?

A

Variety of chemicals to defend against pests and pathogens.

40
Q

What are some chemicals used as drugs to treat human diseases or relieve symptoms?

A

A lot of current medicines were discovered by studying plants used in traditional cure. E.g. aspirin used as painkiller and to lower level fever. Developed from chemical found in willow. Digitalis used to treat heart conditions. Developed from chemical found in foxgloves.

41
Q

What drugs were extracted from microorganisms?

A

Alexander Fleming was clearing out some Petri dishes containing bacteria. Noticed 1 of dishes of bacteria also had mould on it and area around mould was free of bacteria. Noticed that mould on Petri dish was producing substance that killed bacteria-called penicillin.

42
Q

What is the pharmaceutical industry for?

A

Making drugs on large scale-they’re synthesised by chemists in labs. However, process still might start with chemical extracted from plant.

43
Q

What is preclinical testing?

A

Drugs tested on human cells and tissues in lab. However, can’t use human cells and tissues to test drugs that affect whole or multiple body systems e.g. testing drug for blood pressure must be done on whole animal because has intact circulatory system.

44
Q

how are drugs tested on live animals?

A

To test for efficacy (whether drug works and produces affect looking for), to find out about toxicity (harm level) and find best dosage (concentration that should be given, and how often should be given).

45
Q

What is law in UK for drug testing?

A

New drugs must be tested on 2 different live animals. Some think it’s cruel to test on animals, others believe is safest way to make sure drug isn’t dangerous before given to humans. Some think animals are so different from humans that testing on animals is pointless.

46
Q

What happens if a drug passes the test on animals?

A

Is tested on human volunteers in clinical trial. First drug tested on healthy volunteers, to make sure doesn’t have any harmful side affects when body is working normally. At start of trial, very low dose of drug is given and is gradually increased.

47
Q

What happens if the test on healthy volunteers are good?

A

Drugs can be tested on people more suffering form illness. Optimum dose is found- is dose of drug that’s most effective and has few side effects.

48
Q

How is the drug tested on people suffering from the illness?

A

patients randomly put into 2 groups. 1 is given new drug, other is given a placebo. This is so doctor can see actual difference drug makes-allows for placebo effect.

49
Q

How are clinical trials blind?

A

patient in study doesn’t know whether getting drug or placebo. Often double-blind-neither patient nor doctor knows until results have been gathered. So doctors monitoring patients and analysing results aren’t subconsciously influenced by knowledge.

50
Q

What happens with results of testing and trials?

A

Aren’t publish until been through peer review (when other scientists check that work is valid and has been carried our rigorously). Helps to prevent false claims.

51
Q

What are antibodies produced by?

A

B-lymphocytes-type of white blood cell.

52
Q

What are monoclonal antibodies?

A

Produced form lots of clones of single white blood cell. Means all antibodies are identical and will only target 1 specific protein antigen. However, can’t grab lymphocyte that made antibody and grow more-lymphocytes don’t divide very easily.

53
Q

What are positives of tumour cells?

A

Don’t produce antibodies but divide lots-so can be grown really easily. Is possible to fuse mouse B-lymphocyte with tumour cell to create cell called hybridoma.

54
Q

How can hybridoma cells be cloned?

A

Cloned to get lots of identical cells . These cells all produce same antibodies (monoclonal antibodies). Antibodies can be collected and purified.

55
Q

How can you make monoclonal antibodies that bind to anything you want e.g antigen that’s only found on surface of 1 type of cell?

A

Monoclonal antibodies are really useful because will only bind to (target) this molecule-means can use them to target a specific cell or chemical in body.

56
Q

What is the hormone called HCG

A

found in urine of woman only when pregnant. Pregnancy testing sticks detect this hormone.

57
Q

How do pregnancy testing sticks work?

A

Bit of stick wee on has antibiotics to hormone, with blue beads attached. Test strip (bit of stick that turns blue if pregnant) has more antibiotics to hormone stuck on it (so can’t move). If pregnant and wee on stick: hormone binds to antibodies on blue beads, urine moves up stick, carrying hormone and beads, beads and hormone bind to antibodies on strip, so blue beads get stuck on strip, turning it blue.

58
Q

What happens if you use a pregnancy stick and aren’t pregnant?

A

Urine still moves up stick, carrying blue beads. But nothing to stick blue beads into test strip, so doesn’t turn blue.

59
Q

What do different cells have on their surface?

A

Different antigens. So can make monoclonal antibodies that will bind to specific cells in body

60
Q

What do cancer cells have on their cell membrane?

A

Antigens that aren’t found on normal body cells. Called tumour markers. In a lab can make monoclonal antibodies that will bind to tumour markers.

61
Q

What is the use of a anti-cancer drug on monoclonal antibodies and how are antibodies given to patients?

A

Can be attached to monoclonal antibodies. Might be radioactive substance, a toxic drug or chemical which stops cancer cells growing and dividing. Antibodies are given to patient through drip.

62
Q

What do antibodies target?

A

Specific cells (cancer cells) because only bind to tumour markers.

63
Q

What do drug kill?

A

Cancer cells but doesn’t kill any normal body cells near tumour.

64
Q

What are the uses of monoclonal antibodies used for?

A

Bind hormones and other chemicals in blood to measure their levels, to test blood samples in labs for certain pathogens, to locate specific molecules on cell or in tissue.

65
Q

How can monoclonal antibodies locate molecules on cell or in tissue?

A

First monoclonal antibodies are made that will bind to specific molecules you’re looking for, antibodies are present in sample in sample analysing, monoclonal antibodies will attach to them, and can be detected using dye.

66
Q

What are positives of monoclonal antibodies?

A

Cancer treatment. Other cancer treatments (e.g. standard chemotherapy and radiotherapy) can affect normal body cells as well as killing cancer cells, whereas monoclonal antibodies target specific cells. Means side effects of antibody-based drug are lower than for standard chemotherapy or radiotherapy.

67
Q

What are the negatives of monoclonal antibodies?

A

More side effects than originally expected e.g. can cause fever, vomiting and low blood pressure. When were first developed, scientists thought that because targeted very specific cell or molecule, wouldn’t create a lot of side effects.

68
Q

What are the results of the problems of monoclonal antibodies?

A

Not as widely used as treatments as scientists had originally thought they might be.

69
Q

What do plants need and where do they get them from?

A

Mineral ions from soil if aren’t enough plants suffer deficiency symptoms. Nitrates are needed to make proteins and therefore for growth. Lack of nitrates causes stunted growth. Magnesium ions are needed for making chlorophyll, needed for photosynthesis. Plants without enough magnesium suffer from chlorosis and have yellow leaves.

70
Q

Can plants get diseases?

A

Can be infected by viral, bacterial and fungal pathogens. Can also be infested or damaged by insects. E.g. aphids are insect that can cause huge damage to plants.

71
Q

What are easy common symptoms of disease on plants?

A

Stunted growth, spots on leaves, patches of decay (rot), abnormal growth, e.g. lumps, malformed stems or leaves, discolouration.

72
Q

What are symptoms to spot of infestation of pests of plants?

A

Look up signs in gardening manual or on gardening website. Taking infected plant to lab, where scientists can identify pathogen. Using testing kits that identify pathogen using monoclonal antibodies.

73
Q

What are physical defences of plants against disease?

A

Most plants leaves and stems have waxy cuticle, which provides barrier to stop pathogens entering. Plant cells themselves are surrounded by cell walls made from cellulose. These from physical barrier against pathogens that make it past waxy cuticle. Plants have layers of dead cells around stems, e.g. outer part of bark on trees. These act as barrier to stop pathogens entering.

74
Q

What are chemical defences of plants against disease?

A

Some can produce antibacterial chemicals which kill bacteria-e.g. mint plant and witch hazel. Other plants produce poisons which can deter herbivores e.g. tobacco plants.

75
Q

What are mechanical defences of plants against disease?

A

Some plants have adapted to have thorns and hairs. These stop animals from touching and eating them. Other plans have leaves that droop or curl when something touches them. Means that they can prevent themselves from being eaten by knocking insects off themselves and moving away from things. Some plants can cleverly mimic other organisms. E.g. passion flower has bright yellow spots on leaves which look like butterfly eggs. Stops other butterflies laying their eggs there. Several species of plant in ‘ice plant family’ in southern Africa look like stones and pebbles. Tricks other organisms into not eating them.