Topic 11 Flashcards
Action potential
All or nothing signal or communication event, generated by an eletrially active cell (neurons or muscles)
Depolarized
moving away from the polarized state, and movs to more neutral
Repolarization
moves back towards the negative starting pole
Hyperpolization
moves polarity start past the starting and makes membrane event even more negative than what it started with
Threshold
minumum voltage change needed to start an action potential
Voltage-gated ion channel
the protein transport channels are specific to certain ions (Na+, K+, etc.) Voltage gated means that the proteins respond to voltage along the membrane
Steps of Action potential
- Resting membrane potential
2.Slow depolarization - Fast Depolarization
4.Repolarization
4b. Threshold - Hyperpolarization
- Resting membrane potential
Phase 1 A.P
Resting Membrane Potential
-All voltage-gated channels are closed
-ATPase and leak channels have stabilized the membrane voltage arond -70mV
Events during Phase 2 & 3 A.P
Slow Depolarization to Fast Depolarization
-Voltage-gated Na+ channels are open
-Intially a few of the voltage-gated Na+ channels open
-Sodium moves into cell, membrane depolarizes
-Threshold: when there is enough of a voltage change along the membrane, it trips the remaining voltage-gated Na+ channels to open, moving into fast depolarization
Events at the end of Phase 3 and start of phase 4
Fast Depolarization into Repolarization
-voltage-gated sodium channels have closed, no longer to open again (at least until reset)
-Voltage gated potassium channels have opened, potassium flows out of the cell, taking positive charges with it, causes the interior along membrnae to retrun to a more genitive state (repolarizes)
Phase 4 into 5
Repolarization into Hyperpolarization
Voltage-gated K+ channels are open
Phase 5 into 6
Hyperpolarization to Resting membrane potential
-All voltage-gated K+ channels closed but slow to close, so a little too much potassium (positive) leaves, causing the mmebrnae to overshoot its negative (-70 mV pole, and becomes hyperpolarized)
Phase 6:
Na+/K+ ATPase pumps, and leak channels restoring the resting state
Conduction
wave of voltage change that sweeps down the axon, but it doesn’t actually carry any physical moleule with it. The voltage change serves as the signal
Refractory period
period of time when the voltage-gated sodium channels have already been triggered and they aren’t in their ready to respond position anymore, but their gates are closed
Saltatory Conduction
jumping movement of the action potential from node (no myelin along the axon) to node