Topic 10: Inflammatory Arthritides Flashcards
T/F: Inflammatory Arthritides may develop as a primary disorder, and some develop as a secondary disorder.
True
__________ _________ is a chronic, systemic inflammatory disease of joints and connective tissue.
Rheumatoid Arthritis (RA)
Peak incidence of Rheumatoid Arthritis is among _____ aged __-__
Women aged 40 - 60
While idiopathic, RA is thought to be autoimmune in origin. 70% to 80% of RA sufferers test
positive for ___________ ________ - an auto-antibody
Rheumatoid (RH) factor
RH factor combines with IgG to form ________ ________, which are found in the synovium,
synovial fluid, and extra-articular lesions of persons with RA.
Immune complexes
T/F: Osteoarthritis is more prevalent than rheumatoid arthritis with young people.
False
T/F: Osteoarthritis is more prevalent than rheumatoid arthritis with young people.
False
What type of arthritis is associated with inflammatory synovitis and irreversible structural damage to cartilage and bone?
Rheumatoid arthritis
What type of arthritis can affect any joint, usually weight bearing joints, usually asymmetrical?
Osteoarthritis
What type of arthritis is associated with morning stiffness for 1 hour or more (as opposed to ~30 minutes)?
Rheumatoid arthritis
True or false: Rheumatoid arthritis has a variety of systemic signs and symptoms (sickness, fatigue, weight loss) whereas Osteoarthritis has none.
True
Stage _ of RA is __________ - Inflammation of the synovial membrane and joint effusion
Stage 1- Synovitis
Stage _ of RA is _________ ___________ - an abnormal form of granulation tissue - an extensive network of new blood vessels forms in the synovium which contributes to the inflammation. Enzymes are released that destroy articular cartilage and bone.
Stage 2 is Pannus Formation
Stage _ of RA is __________ - Intra-articular adhesions form as a result of the inflammation. These will lead to decreased ROM of associated joints.
Stage 3 is Fibrosis
Stage _ of RA is _____ _________ - Calcification of the panni and fibrous tissue. This leads to joint fusion, which leads to deformity, and disuse atrophy.
Stage 4 is Bony Ankylosis
T/F: Flare up and remission are common with Rheumatoid arthritis.
True
T/F: Presentation of Rheumatoid arthritis is usually bi-lateral, though typically not symmetrical.
False: presentation is usually bi-lateral and symmetrical.
With rheumatoid arthritis, the most commonly affected joints are in the ______, ____ and _____.
Hands, feet and knees.