Top 200 Flashcards
ADRs w/ glimepiride
weight gain
edema
C/I w/ sulfaonylureas
getstation DM or T1DM
MOA of sulfonylureas
stimulates insulin release from Beta cells
Drug C/I w/ CrCl <22
Glimepiride
sulfonylurea w/ greater risk of hypoglycemia
glyburide
sulonylurea C/I if CrCl <10
Glipizide
DDP-IV inhibitior, increases insulin synthesis and lower glucose secretion
sitagliptan
lower total LDL and TG
increases HDL
Atorvastatain
rapid acting insulins
Novolog
Humalog
decreases production of HGP and intestinal glucose absorption
Metformin
bisphosphonate
used to tx osteoporosis, paget’s dz, reduce hypercalcemia in tumor-induced bone dz
alendronate
Bisphosphonate given once a month to tx and prevent osteoporosis in postmenopausal women
Ibandronate (Boniva)
Reduces uric acid synthesis
allopurinol
acetylhcolinesterase inhibitior
used for mild-moderate dementia w/ Alzheimers
Donepezil
DOC for hypothyroidism, goiter, chronic
levothyroxine
2 basal insulins
insulin detemir
insulin glargine
cholesterol absorption inhibitor used for hypercholesterolemia, dyslipidemia, etc
Acts on total cholesterol (stains don’t)
ezetimibe
TZD used for DMT2. Can cause new onset HF
Pioglitazone
fibrate used for high cholesterol.
Decreases everything except increases LDL
also can cause neutropenia
fenofibrate
rapid acting insulins
insulin aspart
insulin lispro
when are statins C/I (Rosuvastatin
Simvastatin)
pregnancy
what must you monitor with sitagliptin?
renal function
what is the difference b/w methylprednisolone and prednisone?
prednisone can only be given oral
when should glipizide be administered?
30 minutes before 1st main meal
C/I w/ sulfonylureas
pregnancy