Tooth morphogenesis Flashcards
The tooth type that forms depends on the ……. genes in the ………. into which the tooth germ ………
homeobox
mesenchyme
invaginates
The primary enamel knot expresses 4 signalling moles :
Fgf-4 (fibre growth factor)
Wnt10B (wint10B)
Shh (sonic hedgehog)
Bmp-4 (bone morphogenetic protein 4)
What signalling molecules stimulate growth and proliferation of the dental epithelium
Fibre growth factor 4 (Fgf-4) Sonic hedgehog (Shh)
The enamel knot expresses …….. factors but does not express …….. so can not respond to its own ….
growth
receptors
signal
The enamel knot not having receptors leads to high ………. outside the enamel knot and low …….. within the enamel knot, result in …… of the ……. epithelium
proliferation
proliferation
folding
dental
The enamel knot does not …… so does not respond to ……..
grow
signals
Loss of focal adhesion kinases blocks ……… ………..
cap formation
What signals death of the enamel knot (silencing the signal centre - apoptosis)
Bmp4
What expresses the secondary enamel knot and causes cells to proliferate
Fgf4
Height of cusps is linked to timing of initiation of …….. ……. …….
secondary enamel knots
What occurs to teeth and cusps in hypohidrotic ectodermal dysplasia
What signalling is too less
What occurs to the enamel knot
What occurs to the teeth in the future
reduced teeth + flattened cusps Eda reduced in size/abnormal shape loss of bulge at cap stage teeth erode v quick
What is tooth morphogenesis controlled by
enamel knots
What controls the transition from bud to cap?
proliferation
What factors of cells drive the tooth shape
cell movement
cell shape rearrangements
with proliferation difference
The size and shape of the …….. …….. ……. is critical for controlling cusp …… and ……….
primary enamel knot
shape
size
