Early tooth development Flashcards
5 stages of tooth development
dental lamina > Initiation > bud stage > cap stage > bell stage
Dental tissues originate from two tissues;
epithelium (oral epithelium, ectoderm)
mesenchyme (neural crest cells)
Epithelium derivative
enamel
Mesenchyme derivatives
dentin, pulp, PDL, alveolar bone socket, cementum
What communication is vital for tooth to be present
epithelial-mesenchymal communication
oral ectoderm + mesenchyme adjacent
What do neural crest cells under go
What do they originate from and transform into
epithelial-to-mesenchymal transition (EMT)
NCCs originate from ectoderm + transform into mesenchyme
What cells are inside the dental pulp and PDL
fibroblasts
Treacher Collin syndrome mutation is ……. essential for ……. survival. They also have …….. palate
TCOF1 gene
neural crest cells
cleft
What expression is important in tooth initiation and what is it crucial for?
Sonic hedgehog
thickening
What is morphogenesis
determination of tooth crown shape by epithelial folding
- combination of cell proliferation + movements
two types of condensed mesenchyme
dental follice
dental papilla
What does the dental follicle surround and give rise to
tooth germ
cementum, PDL, alveolar bone socket
What does the dental papilla lay beneath and what does it give rise to
epithelium cap
dental pulp
odontoblast which secrete dentine
4 distinct cell types of the enamel organ
stellate reticullum
stratum intermedium
inner enamel epithelium
outer enamel epithelium
What signalling is key for bud to tooth
BMP signalling
Bone Morphogenetic Protein
