Tolerance and Dependence

Question 1

What is tolerance?

Answer 1

When it becomes necessary to increase the dose of a drug to obtain an effect previously obtained by a smaller dose.

Question 2

What causes tolerance?

Answer 2

Reduced sensitivity of the receptor sites and increased rate of metabolism in the liver.

Question 3

How can you stop tolerance?

Answer 3

Normal sensitivity can be regained by stopping the drug.

Question 4

Examples of CNS depressents which tolerance can arise from.

Answer 4

heroin, morphine, barbituates, diazepam, alcohol

Question 5

Examples of CNS stimulants which tolerance can arise from.

Answer 5

dexamphetamine, methylamphetamine

Question 6

What is drug dependence?

Answer 6

A state arising from repeated, periodic or continuous administration of a drug that results in harm to an individual and sometimes society.

Question 7

Psychic dependence is…?

Answer 7

When emotional stress occurs if the drug is withheld

Question 8

List some drugs which can cause dependence from mild to severe dependence.

Answer 8

vitamins, laxatives, aspirin, diazepam, tobacco, barbiturates, amphetamines, morphine

Question 9

Physical dependence…?

Answer 9

Refers to an altered physiological state caused by repeased administration of the drug.