Tobacco Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

Who were the first users of tobacco and around what year

A
  • Mayans in Central America around 300AD
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2
Q

When the Europeans landed in the New World what did they see the Native people doing with tobacco and when did they bring it back to Europe? What was the general reaction of people?

A
  • Europeans saw that the Natives would roll up tobacco leaves into rods, light them and insert them into their nostrils
  • brought back tobacco to Europe in the mid-1500s
  • people had general enthusiasm and believed it to have a wide range of medical powers (ie. believing if you insert tobacco smoke into the rectum of someone dying it would save them)
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3
Q

How was tobacco primarily used in the 1600s? Who used it more?

A
  • smoked using a pipe
  • occurred in all segments in society and in both sexes
  • gathered in tobacco houses (similar to opium dens)
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4
Q

How was tobacco primarily used in the 1700s?

A
  • tobacco was used in the form of snuff

- finely ground tobacco and pinches were taken and snorted into the nasal passage (“taking snuff” was an art)

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5
Q

How was tobacco primarily used in the 1800s?

A
  • chewing tobacco
  • Loose-leaf chew: shredded tobacco leaves
  • Plugs: shredded tobacco was mixed with ingredients like molasses and then pressed into a rectangular cube
  • rolled tobacco cigars became popular in North America around this time too
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6
Q

James Bonsack (1881)

A
  • invented the cigarette machine (increased consumption)

- cigarettes began to appear in the 1850s

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7
Q

How many cigarettes can a modern machine produce per minute?

A
  • 20,000
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8
Q

King James I (1566-1625) of England

A
  • published a Counterblast to Tabacco refuting the medical benefits of smoking
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9
Q

Pope Urban VIII (1624)

A
  • issued a worldwide ban among Catholics because be he felt that sneezing resulting from snuff use too closely resembled sexual ecstasy
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10
Q

Sultan Murad IV (1633)

A
  • prohibited smoking in the Ottoman empire and roamed the streets to enforce the rules himself
  • beheaded if they were found
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11
Q

Czar Michael of Russia

A
  • banned smoking in 1634 and enforced it through physical punishment for first time offenders and death for second time offenders
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12
Q

What is part of the “Cushions on the sofa of pleasure”?

Did the bans last?

A
  • coffee, wine, opium and tobacco

- tobacco bans were short-lived

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13
Q

The Anti Cigarette League

A
  • formed in the United States in 1899

- lead by Lucy Gaston who stated that cigarettes are “coffin nails”

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14
Q

What did the Canadian Parliment do in regards to tobacco and what came out of it?

A
  • tried to enforce restrictions and laws for every year for the first decade and a half of the 20th century
  • passed some laws restricting sell of tobacco to minors
  • these banning and legislative attempts failed and essentially came to an end with the start of WWI when sending cigarettes to soldiers overseas was seen as patriotic
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15
Q

Why did smoking increase in the US and Canada? When did it peak?

A
  • smoking increases bc smoking was advertised as sexy and glamourous
  • peaked in the US around 1964 when 40% of US adults were smoking (4300)
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16
Q

Why did smoking start to decline?

A
  • 1964: a report linking smoking to cancer

- since the mid-60s smoking has decreased in Canada and the US

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17
Q

what was the popualtion of smokers in Canada in the 50s?

A
  • 70% but the percentage has been decreasing to a current rate of 13% (10% being daily smokers)
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18
Q

has smoking declined around the world?

A
  • No, smoking has declined in North America but high rates of smoking in some countries like China (males 55%) and increasing in some developing countries
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19
Q

What is the heavy cost that smoking has on society and the individual?

A
  • adverse health costs
  • costs Canadians more in health expenses, lost productivity and premature death than the total for either alcohol or illegal drugs
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20
Q

how many minutes is taken from a users life with each cigarette?

A
  • 14mins

- smokers die as early as 12yrs than a non-smoker

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21
Q

Mainstream smoke

A
  • smoke exhaled by the smoker
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22
Q

Sidestream smoke

A
  • smoke emanating from lit tobacco

- more dangerous than mainstream smoke bc it hasnt been filtered by the cigarette and the lungs

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23
Q

Living and working in a place where smoking is permitted increases a nonsmokers risk of developing heart disease or cancer by __%
Is there evidence that links babies exposed with secondhand smoke and SIDS?

A
  • 30%

- YES

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24
Q

Environmental tobacco or second-hand smoke

A

Mainstream smoke + sidestream smoke

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25
Q

Smoking and genetic evidence

A
  • Belskey et al. study examined thousands of genomes of smokers and found some variants in and around genes that affect how the brain responds to nicotine and how nicotine is metabolized being more common in heavy smokers
  • females = heavy genetic influence
  • males = same as alcohol dependence genetic influence
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26
Q

Smoking and certain demographic factors

A
  • adolescent age, low SES, less education and high levels of coffee or alcohol consumption are more common in smokers than nonsmokers
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27
Q

Smoking and gender

A
  • females see smoking as a way to maintain their weight more than men do (40% of females reported this as the primary reason to smoke)
  • nicotine is an appetite suppressor
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28
Q

Smoking and psychological factors

A
  • smokers tend to exhibit low conscientiousness, low agreeableness, high extroversion, increases neuroticism, more anxiety, less self-control and less morningness-more eveningness
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29
Q

Smoking and childhood experiences

A
  • relationship between adverse childhood experiences (ACE’s) and smoking
  • suggesting that smoking may be used as a form of pharmacological relief from unpleasant experiences
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30
Q

Smoking and social influences

A
  • smoking by peer groups and parental smoking, dispose of smoking
  • cigarette use by movie stars and advertisements are associated with increased smoking
31
Q

Smoking and mental disorders

A
  • higher incidence
  • smoking occurs in 41% of individuals with a current mental disorder
  • depression is one of the most frequent mental illnesses comorbid with smoking
  • evidence that nicotine may have antidepressant effects (might be smoking as a form of self-medication)
  • transdermal patches help non-smokers with depression
32
Q

Comorbidity and smoking

A
  • present in individuals with alcohol dependence so its not surprising that smoking, drinking and depression often occur together
33
Q

What is the psychoactive ingredient in tobacco?

A

nicotine

34
Q

Jean Nicot

A
  • named after him (French Ambassador to Portugal)

- first purified in 1828 by 2 french chemists Posselt and Reimann

35
Q

Characteristics of nicotine

A
  • oily, either colourless or brown colour with an unpleasant smell
36
Q

what is the most efficient means of administration of nicotine?

A
  • inhalation - can reach the brain in 7s

- also absorbed through the skin - which is why some people would die in the past bc it was put in the insecticide

37
Q

what is the main metabolite in nicotine?

A
  • cotinine

- presence of cotinie in the urine is used as a marker for tobacco or evidence of exposure through second-hand smoke

38
Q

how much nicotine goes unchanged when extreted and how is the amount of nicotine excreted influenced by?

A
  • 30-40% of nicotine goes unchanged when excreted

- the amt extreted is highly dependent on urine pH

39
Q

What does alkalinizing the urine do?

A
  • since nicotine is a base when the urine is alkaline this leads to greater renal absorption meaning that nicotine is taken back up into the blood and not excreted
  • this can reduce smoking by keeping nicotine in the blood longer
40
Q

What does acidification of the urine do?

A
  • smokers smoke at a higher rate bc more nicotine is extreted
  • stress results in the acidification of urine so smokers will have to smoke more under stressful conditions bc the nicotine is being excreted
41
Q

What receptors does nicotine activate? and where are these receptors located?

A
  • nicotine cholinergic receptors
  • receptors are located on the dopminergic neurons in the mesocorticolimbic dopamine sys projecting from the VTAto the nucleus accumbens (NA) and the prefronttal cortex
42
Q

what happens when the nicotine receptors on the dopamine neurons are activated?

A
  • leads to the stimulation of dopamine release

- nicotine also stimulates the release of glutamate which releases more dopamine

43
Q

what does nicotine do to the GABA pathway?

A
  • initial increase in GABA activity to lesson all the dopamine activity but nicotine interferes with this modulatory action of GABA towards dopamine meaning there is a sustained dopamine activation
44
Q

Self-administration paradigm

A
  • nicotine is a reliable reinforcer
  • guages the relative reinforcing properties of different drugs or even drugs in relation to other reinforcers like food, water and sex
  • in humans you can ask them how much are they willing to pay for that outcome
45
Q

Progressive ratio procedure - what is it and how does it work?

A
  • self-administration paradigm that provides info on the reinforcing properties of a drug
  • the animal is trained to press the bar to receive a drug infusion - initially, the number of bar presses is low but increases as they show that they will work for the drug
46
Q

Breaking point

A

the largest number of responses that the animal will make to obtain the drug

  • a breakpoint is different on each drug
  • cocaine has the largest breakpoint
47
Q

What is the antagonist for nicotine (3) and what does this show?

A
  • mecamylamine (nicotine receptors)
  • rimonabant (cannabinoid receptors)
  • naloxone (opiate receptors)
  • this shows that its a complex system of the reinforcing effects of nicotine as it interacts with several neurotransmitter systems
48
Q

Smoking topography and what is dependent on it?

A
  • refers to the characteristics of how a cigarette is smoked, delivery of constituents being depth and volume of inhalation, how long smoke is held in the lungs and whether in the filter are covered or uncovered
  • the amt of nicotine, tar and carbon monoxide is dependant on smoking topography
49
Q

how come the values of constituents (nicotine, tar and carbon monoxide) are no longer printed on cigarette boxes - why were they there originally?

A
  • these values were there for smokers to make informed decisions about smoking
  • the smokers didn’t use this information and it was misleading bc it was dependant on the smoking topography of the smoking machine
  • unless a human was to smoke like the machine the levels of the constituents vary so it’s not present on cigarette boxes
50
Q

“Light” Cigarettes - facts and how does it differ from “light” beer?

A
  • the values printed on a light cigarette box suggested that there were fewer constituents in this box than in a regular cigarette box but it’s possible that a light cigarette could deliver more constituents than in a regular cigarette
  • the holes on the filter of the light cigarette and a major mechanism for how it delivers its constituents is allowing air to be sucked into these holes diluting the smoke (but this dilutes the smoke and produces a less satisfying smoke to smokers)
  • realized that the flavour of a light cigarette can be enhanced by placing the fingers in a certain location on the filter - covering the holes
  • if the smoker believes that a light cigarette is better for them they will hold the smoke in longer in their lungs causing more damage than a smoker holding in the smoke for a shorter time with a regular cigarette
  • differs from “light” beers bc the only way to change the amount of alcohol consumed in a light beer is to simply drink more
51
Q

What are the primary effects of nicotine?

A
  • affects the brain stem vomiting centre
  • increases heart rate and BP and constricts blood vessels (leaving smokers with cold and clammy hands/feet)
  • males may experience impotence over the course of long-term smoking
  • for men under 40 smoking is the biggest cause for erectile dysfunction (need a healthy blood supply and nicotine causes your blood vessels to contract)
52
Q

what is the toxic dose of nicotine?

A
  • 60mg in an adult and a cigar has 2 lethal doses

- not all of it is inhaled when someone smokes a cigar

53
Q

what are the 2 harmful constituents in a cigarette and how many compounds are released during smoking?

A
  • 4000 compounds

- tar and carbon monoxide

54
Q

what is Tar and what is a proposed solution to inform smokers about the amount of tar they may take into their bodies?

A
  • tar refers to any other substance in tobacco smoke that isn’t nicotine and carbon monoxide
  • suggested to include pictures of the “butt colour” on packages - by inspecting the filter on a cigarette the brown stain represents tar ao the darker the colour is the more tar that individual has inhaled (real-time assessment)
55
Q

Marijuana smoke or tobacco smoke - which is more harmful?

A
  • marijuana smoke is more harmful: contains more carbon monoxide, and more cancer-causing chemicals
  • marijuana smokers hold the smoke in longer to achieve the “high” causing more damage to the lungs
56
Q

Tobacco smoke and Carbon Monoxide

A
  • binds to haemoglobin forming carboxyhemoglobin which reduces the oxygen-carrying capacity of the blood
  • smoking 1 cigar reduces the oxygen-carrying capacity of blood by an amount equal to the loss of 250cc of blood
57
Q

Tobacco smoke and Pregnancy - maternal effects, and paternal effects

A
  • up to 20% of women smoke during pregnancy
  • both effects from direct maternal smoking and indirect second-hand smoke (ie. from the father)
  • maternal tobacco smoking is associated with an increased incidence of spontaneous abortion, stillbirths and premature births
  • developmental delays in math, reading and general intellectual markers, externalizing behaviour, reduced intellectual abilities (ie. 5 points lower than standard IQ), increased incidence in ADD and hyperactivity
  • 10+ cigarettes a day are associated with a clear increase risk for deficits
  • smoking depletes Vitamin C and sperm of men who have low vitamin C have been found to be abnormal - related to birth defects like cleft palate and lip
58
Q

nicotine and cholinergic system

A
  • the cholinergic system involved in learning and memory
  • nicotine improves information processing and memory and enhances the performance in tasks requiring concentration over a longer period of time
  • reduces the interference from irrelevant stimuli and increase attention to relevant stimuli
59
Q

Stroop Task

A
  • shown colour names printed in colours not corresponding to the name itself
  • requires the participant to ignore the semantic content and concentrate on the colour print
  • nicotine enhances the concentration by ignoring the irrelvant semantic stimuli and naming the colours faster under nicotine than comapred to no nicotine
  • nicotine may help alleviate some cognitive deficits in Alzheimer’s
60
Q

Modified version of the Stroop Task

A
  • studies the attentional bias towards stimuli related to the substance or behaviour
  • basically, participants are shown words that reasonably are associated with the substance/behaviour (ie. TARGET WORDS) and words that aren’t associated with the substance/behaviour (ie. NEUTRAL WORDS)
  • the words are printed in different colours and the individual must name the colour of the print
  • it was found that depressed people are slower to name the colour of the print of the target words than a non-depressed person (Stroop interference)
  • both groups were able to name the colours of the words that didn’t relate to the substance/behaviour
  • accepted as a way to determine if ppl have an intentional bias towards stimuli related to the disorder
61
Q

Stroop interference

A

can’t name the colour of the target words

62
Q

Dot and probe task

A
  • a participant is shown 2 images on a split screen (one related to the substance or behaviour and the other isn’t)
  • the screen comes on and goes off quickly following it with a stimulus (ie. a dot) on either the left or right screen and they must indicate what side of the screen it appeared
  • results show that ppl with a disorder are more quickly able to locate the dot-probe if it appears on the same side as the initial substance-related screen
  • used to study attentional bias
63
Q

nicotine and tolerance, sensitization and physical dependence

A
  • little ecivdence of tolernace to many cognitive enhancing effects or to reinforcing or dopamine releasing effecrs
  • clear evidence to sensitization to the locomotor stimulants effects of nicotine
  • clear evidence of physical dependence bc tehre are withdrawal symptoms: decrease arrousal, sleep disturbances, restlessness, attentioanl deficits, tension, irritability, headaches, increased appetite (weight gain) and cravings
  • most withdrawal symptoms last for 10-30 days but cravings can last up to years later
  • tobacco withdrawal and cannabis withdrawal are similar but differ in the sense that tobacco withdrawal increases appetite and cannabis withdrawal decreases appetite
64
Q

what is the typical trend for the cessation of smoking?

A
  • numerous cycles of quitting and relapsing
  • the relapse rate for returning to smoke after quitting is high - estimated that one-year relapse rates ate to be no lower than 80%
65
Q

what are the characteristics of a more successful quitter? do women or men find it hard to stay quit?

A
  • older
  • male
  • married
  • smoking fewer cigarettes
  • lower addiction level
  • smoked for fewer years
  • more previous quit attempts
  • higher self-efficacy
  • women find it more difficult to quit and stay quit than men
66
Q

how do women smoke compared to men?

A
  • women smoke fewer cigarettes per day
  • smoke brands with less nicotine
  • inhale less deeply
  • all of which should make it easier for women to quit but it is suggested that women smoke not for the nicotine aspect but for sensory effects of smoking, conditioned cues of smoking or the social pleasures involved with smoking
  • nicotine replacement therapy is more effective in men than women
67
Q

Nicotine replacement therapy

A
  • nicotine is delivered by some other means than smoking
  • the use of a transdermal patch, chewing gum or a nicotine nasal spray or inhaler (not the same delivery time as smoking)
  • the rationale is that if the smoker is smoking just for the nicotine this is a safer way to still have nicotine in the blood and gradually the person can wean off of it
  • but there is evidence that the reinforcing factors of smoking are not solely due to the delivery of nicotine
  • this helps to reduce the withdrawal effects it does nothing on the self-reported craving for a cigarette
68
Q

Bupropion (Zyban, Wellbutrin)

A
  • nicotine receptor antagonist and blocks dopamine reuptake
  • originally marketed as an antidepressant
  • more helpful in smoking cessation than nicotine replacement therapy
69
Q

Successful quitting

A
  • not smoking for 6 months or 1-year post-treatment
70
Q

Varenicline (CAN = Champix, US = Chantix)

A
  • modification of a naturally occurring plant substance: cytosine
  • weak nicotine cholinergic agonist (partial receptor agonist)
  • it attaches itself to the nicotine receptors but doesn’t produce the same level of agonism (activation) as nicotine does
  • while the nicotine receptors are occupied they cannot be occupied by the nicotine so there is a reduced level of nicotinic stimulation and thus reduced dopamine levels
  • effective at both reducing withdrawal symptoms and cravings and it’s more effective than nicotine replacement therapy and bupropion
  • found and used in Westen EurAsia
71
Q

Vaping

A
  • inhaling vapours produced by some type of electronic device
  • may contain nicotine
  • vapours appear smoke-like although the cloud is ticker than tobacco smoke
  • called an e-cigarette when device looks like a cigarette
  • first occurred in the 1960s
  • vaping is less harmful than smoking cigarettes as it allows them to get the nicotine but with less harmful effects (but if e-liquid has nicotine it can lead to dependence)
  • in Ontario, it’s illegal to sell e-cigarettes to anyone under 19
72
Q

EVALI

A

e-cigarette, vaping associated lung illness

73
Q

Heat-not-burn cigarettes

A
  • heat actual tobacco to a point just below combustion but to a temperature that vaporizes the nicotine in the tobacco
  • don’t produce the same smoke or odour as normal cigarettes
  • introduced in the 1990s
  • 2 types:
    1. iQOS (I quit original smoking)
    2. i-glo
74
Q

what is the concern with vaping and smoking?

A

it may re-normalizing smoking in society