Tissue Repair Flashcards
Labile
continuously dividing
Stable
infrequent division
honeycomb lung
pulmonary fibrosis
4 steps of tissues repair
1) Inflammation
2) Cell proliferation/migration
3) ECM creation
4) ECM remodeling
4 steps of ulcer repair
1) necrosis, exudate
2) granulation tissue
3) GT and ECM
4) fibrous scar or regneration
most abundant glycoprotein in the basement membrane
Laminin
cell adhesion proteins (CAM) do what
Link cells and ECM
BM is necessary for
re-epithelization of the ulcer
interstitial matrix consists of
collagen, elastin, fibronectin, proteoglycans, hyaluronate
EGF/TGF-a produced by which cells
Keratinocytes and macrophages
EGF/TGF-a function
Bind to ERB-B1 to combine with tyrosine kinase to induce division of cells
PDGF produced by
platelet alpha granules
PDGF mechanism
two A/B chains that bind with a/ß membrane receptors
PDGF function
induces migration/proliferation in fibroblasts and endothelial cells
FGF mechanism
recognized by cell surface membrane receptors with intrinsic protein kinase activity
FGF function
induce macrophage, fibroblast EC migration, also angiogenesis
TGF-b
phosphorylation of cytoplasmic TF Smad via interact with RII
What does it mean for TGF-b to be pleiotropic
It can be both inhibitory or stimulatory
Which GF is important in development of fibrosis
TGF-b
