Inflammation I and II Flashcards
Outcomes of acute inflammation are
1) complete resolution
2) Fibrosis
3) Chronic
Chronic inflammatory cells are
macrophages, lymphocytes and eosinophils
Lymphocytes are
T cells, B cells and NK cells
CD4+ are
T helper cells
CD8+ are
cytotoxic T cels
3 different types of Th cells
Th1, Th2, Th17
Th1 cells release
pro-inflammatory cytokines such as TNF, IL1, interferon gamma
Th2 cells release
IL4, IL5, IL13
purpose of cd8+ cells is to
kill virally infected and cancer cells
B cell purpose
make antibodies
What are the mediators of chronic inflammation?
Cytokines TNF and IL6 and granulomatous inflammation
How are acute phase proteins measured
Via C-reactive protein or ESR
What induces production of acute phase proteins?
IL6, which stimulate hepatocytes to produce it
When do APP show up?
In acute phase, and stay present until inflammation subsides
What’s granulatomous inflammation a sign of?
chronic inflammation
TB causes what kind of granuloma
caseating granuloma
cells in grauloma
irritant surrounded by macrophages surrounded by lymphocytes
Multi-nucleated giant cells are characteristic of what
granulomas
Why is measuring APP important?
because Il-6 is short-lived
What are the three steps of acute inflammation?
1) Hyperemia
2) Vascular permability
3) Leukocyte accumulation
How are M1 macrophages triggered?
microbial TLR, IFN-gamma
How are M2 macrophages triggered
IL4 or IL13 (anti-inflammatory cytokines)
What are prostaglandins>
Arachidonic acid metabolites that cause hyperemia
What do mycobacteria trigger?
Trigger bacterial infection which triggers granulomatous inflammation
