MSK

Question 1

In which disease is sonic hedgehog implicated?

Answer 1

Basal cell carcinoma

Question 2

which disease has red, elevated, oozing and crusted lesions

Answer 2

Eczema

Question 3

Which disease involves Langerhans cells

Answer 3

Eczema

Question 4

Multifactorial immunological disease

Answer 4

Psoriasis

Question 5

Keratinocyte hyper proliferation is present in

Answer 5

Psoriasis

Question 6

Downward elongation of rate ridges is present in

Answer 6

Psoriasis

Question 7

HPV is implicated in

Answer 7

Verruca Vulgaris

Question 8

IgG, Fishnet pattern are typical signs of

Answer 8

Pemphigus Vulgaris

Question 9

Exophytic proliferation of basal cells with horn cysts is representative of

Answer 9

Seborrheic keratosis

Question 10

Seborrheic keratosis is benign or malignant

Answer 10

Benign

Question 11

Sun-related skin infection is

Answer 11

Actinic keratosis

Question 12

Actinic keratosis can progress to

Answer 12

Squamous cell carcinoma

Question 13

red scaling plaques that respond well to early treatment are

Answer 13

squamous cell carcinoma

Question 14

2nd most common tumor

Answer 14

squamous cell carcinoma

Question 15

slow growing tumor cells

Answer 15

basal cell carcinoma

Question 16

Rodent ulcer: pearly papules that ulcerate and invade adjacent skin

Answer 16

BCC

Question 17

Palisading tumor cells are characteristic of

Answer 17

BCC

Question 18

Nevus cells benign or malignant

Answer 18

Benign, induced to become senescent to prevent malignancy

Question 19

Flat macule with slightly raised plaques variable pigmentation and irregular borders

Answer 19

Dysplastic nevi, progression to melanoma

Question 20

2 stages of malignant melanoma growth

Answer 20

1) Radial
2) Vertical

Question 21

Mutation in CDKN2A

Answer 21

malignant melanoma

Question 22

Mutation of BRAF, NRAS or loss of function in PTEN

Answer 22

Malignant melanoma

Question 23

ABCs of Melanoma

Answer 23

Asymmetry, Border, Color, Diameter, Evolution

Question 24

Percentage of melanomas that carry a BRAF mutation

Answer 24

40-60%

Question 25

Most common primary bone tumor

Answer 25

Osteosarcoma

Question 26

Which mutation increases the risk of osteosarcoma by 1000x

Answer 26

RB mutation

Question 27

Which bone tumor is most common adolescents

Answer 27

Osteosarcoma

Question 28

When does chondrosarcoma usually occur?

Answer 28

Mid-to-late adulthood

Question 29

Benign bone tumor, teens, 20s

Answer 29

Osteoma

Question 30

Is Osteoarthritis degeneration or inflammation of joint cartilage

Answer 30

Degeneration

Question 31

Chonrocyte apoptosis and subcortical cyst formation is representative of

Answer 31

Osteoarthritis

Question 32

Rheumatoid factor can complex with which antibody

Answer 32

IgG

Question 33

Rheum A is mediated by what

Answer 33

Cytokine mediated mainly from CD4+

Question 34

Rheumatoid factor

Answer 34

Autoantibdoes that complex and deposit in joints

Question 35

Cyclic citrullinated peptides (CCPs)

Answer 35

Found in RA, contribute to joint lesions

Question 36

(1;2) translocation is associated with

Answer 36

Tenosynovial giant cell tumor (TGCT)

Question 37

Lipoma is __ and liposarcoma is ___

Answer 37

Lipoma: benign Liposarcoma: malignant

Question 38

Tumor that is prone to recur locally and does not metastasize

Answer 38

Fibromatosis

Question 39

Herringbone pattern is representative of

Answer 39

Fibrosarcoma

Question 40

Fibrosarcoma commonly metastasizes to

Answer 40

the lungs

Question 41

Malignant tumors of fibroblasts are

Answer 41

Fibrosarcoma

Question 42

t(2;13)

Answer 42

Rhabdomyosarcoma

Question 43

Rhabdomyosarcoma is usually found in

Answer 43

under 20 year odls

Question 44

t(X;18) is found in

Answer 44

synovial sarcoma

Question 45

synovial sarcoma age

Answer 45

20-40 years old

Question 46

biphasic growth pattern: glands, spindle fascicles

Answer 46

synovial sarcoma

Question 47

Leiomyoma

Answer 47

Benign

Question 48

Leiosarcoma

Answer 48

Malignant