Tissue Repair

Question 1

Healing

Answer 1

Minimal residual effect

Question 2

Repair

Answer 2

Occurs with tissue loss. It is the restoration of tissue architecture and function after injury

Question 3

Repair by two reactions

Answer 3

Regeneration

Maturation of stem cells

Question 4

Cells and tissue regeneration

Answer 4

Cell proliferation
Growth factors
Intrinsuc proliferative capacity

Question 5

Three groups of tissue groups

Answer 5

Labile
Stabile
Permanent

Question 6

Signals of proliferation growth factors

Answer 6

Multiple cell types
Produced by cells near the site of damage
Signalling pathways : proteins: cell cycle and release blocks on checkpoints

Question 7

Tissue stem cells

Answer 7

Supplement proliferation of residual cells
Live in specialized niches
Triggered by injury
Differentiate into mature cells that repopulate the injured tissue

Question 8

Repair by connective tissue (scar formation)

Answer 8

A response that patches rather than restores. 
If the tissue injury is
- severe/ chronic
- to parenchymal cells
- is non dividing cell

Question 9

Steps in scar formation

Answer 9

Angiogenesis
Formulation of granulation tissue
Remodelling of connective tissues

Question 10

Deposition of connective tissue

Answer 10

1. Migration and proliferation of fibroblasts: site of injury
2. Deposition of ECM proteins produced by these cells

Orchestrated by cyyokine and growth factors

Question 11

Two clinically significant types of repair

Answer 11

Healing of skin wounds

Fibrosis in injured parenchymal groups

Question 12

Abnormalities in tissue repair

Answer 12

Inadequate formation of granulation tissue of formation of scar
Excessive formation of components of repair
Exuberant granulation contractured