Tissue Mechanics Flashcards
Loading Modes
Compression; Tension; Bending; Shear; Torsion; Combined Loading
Structure of connective tissues
Characterized by a wide dispersion of cells in the presence of a large ECM
Interfibrillar components
(Ground substance)
Fibrillar components
(fibrous)
Connective tissues are unique because…
Functions determined by ECM, unlike other tissues where cell behavior determines
Fibroblast
Basic cells of most connective tissue
Fibroblasts may become
Chondroblast
Osteoblast
Tenoblast
With maturation, fibroblasts are…
Fibrocytes
Chondrocytes
Oesteocytes
Tenocytes
Proteoglycans
Attached are one or more polysaccaride chains called glycosaminoglycans (GAGs)
Glycoproteins
Compound containing a carbohydrate covalently linked to protein
GAGs
Negatively charged, a concentration of GAGs creates a swelling pressure and H20 goes into ECF
Collagen fibers counteract GAGs by
resisting and containing the swelling via tensile stress and osmotic pressure
Tissue can resist compression
Tissues subjected to high compression forces have a ___ PG content
High
Tissues that resist tensile loads have a ____ PG content
Low
Collagen
Most abundant protein in the body
Strong as steel
Type I Collagen
predominantly in ligaments. tendons, menisci, and joint capsules
Type II Collagen
Predominantly in hyaline articular cartilage and nucleus pulposus of disk
Elastin
Properties allow the fibers to deform under force and return to original state
Generally less elastin in connective tissue
Connective tissue composition and structure
Sparsely vascularized, parallel fibers
Dense connective tissue in tendon and ligament
Type I collagen production
Fibroblasts make procollagen which is cleaved to produce type I collagen
Coiling of connective tissue
Polypeptide chain coiled in left handed helix
Three alphas chains are then coild in a right handed helix.
Cross links
Formed by GAG’s between collagen molecules
Aid in strength
More elastin in _____ than ____
Ligaments; Tendons
Overload
Tissues increase their structural or functional capability in response to overloading