Tissue Injury and Repair

Question 1

Tissue Regeneration

Answer 1

complete reconstitution
Tissues with high proliferative capacity
Requires viable stem cells and intact connective tissue scaffolding

Question 2

Tissue Repair

Answer 2

combination of regeneration and scar formation
Relative contribution of two processes depends on capacity to regenerate, extent of injury, and extent of scarring/fibrosis

Question 3

Sequence of Healing

Answer 3

Inflammation
Angiogenesis/Neovascularization
Migration and proliferation of parenchymal cells and fibroblasts
Scar formation
Connective tissue remodeling

Question 4

Local factors affecting wound healing

Answer 4

Size
Location (i.e. how well vascularised)
Type (infectious/necrotic/traumatic)
Infections, mechanical forces, foreign bodies delay healing

Question 5

Systemic Factors affecting wound healing

Answer 5

Nutritional status
Metabolic status (e.g. diabetes mellitus)
Circulatory/vascular status
Hormones (e.g. glucocorticoids)

Question 6

Complications of Repair

Answer 6

Excessive repair
-Excessive granulation tissue (proud flesh)
-Excessive collagen accumulation  hypertrophic scar
-Keloid
Formation of contractures