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Pathology > The Urinary System and the Male Genital Tract > Flashcards

The Urinary System and the Male Genital Tract Flashcards

1
Q

Urinary tract infections

A

Very common disorder of the urinary tract

Risk factors include:
Females>males
Sexual intercourse
Pregnancy
Diabetes
Urinary tract obstructions e.g. stones or catheters
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2
Q

Bacterial causes of UTIs

A

E.coli is the most common causative organism (>70% of community UTIs).

Other organisms include: Staphylococcus, Proteus and Klebsiella.

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3
Q

Cystitis

A

frequency
dysuria
urgency
haematuria and super pubic pain

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4
Q

dysuria

A

painful or difficult urination

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5
Q

pyelonephritis

A

high fever
rigors
vomiting
loin pain and tenderness

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6
Q

Prostatitis

A

flu-like symptoms
few urinary symptoms
swollen tender prostate on PR

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7
Q

Management of UTIs

A

Drink plenty of fluids.

Urinate often (double voiding).

Antibiotics (trimethoprim usually first line treatment in uncomplicated UTIs).

Imaging – US in non-resolving UTIs, children, men and pyelonephritis.

Severe cases may require hospital admission specially pyelonephritis and in the elderly

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8
Q

Function of Kidneys

A

Maintinance of water, electrolyte and acid-base homeostasis.
Excretion of many toxic metabolic waste products (urea and creatinine).
Hormonal function
Renin – help control blood pressure
Erythropoietin- stimulates production of RBCs in the bone marrow and helps in the production of vitamin D.
The functional unit is the nephron (consisting of a glomerulus and a renal tubule).
Filtration of most small molecules from the blood in the glomerulus.
Selective reabsorption in the renal tubule of most of the water and some molecules.
Maintenance of the acid-base balance.

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9
Q

Acute renal failure

A

A significant deterioration in renal function occurring over hours or days

There is a low urine volume (

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10
Q

Causes of Acute renal failure

A

Pre-renal
Hypoperfusion, sepsis
Renal
ATN damage to tubules due to ischaemia or nephrotoxins
Post-renal
Renal tract obstruction (eg stones, tumours)

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11
Q

Management of acute renal failure

A

Find and treat the cause

Treat exacerbating factors ( hypovolaemia, sepsis.. etc).

Stop nephrotoxic drugs ( NSAIDs, ACE-I, gentamycin and Vancomycin)

May need renal replacement therapy (haemofiltration/dialysis)

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12
Q

Chronic renal failure

A

Classified into 5 stages depending on the glomerular filtration rate (GFR)

GFR is the volume of fluid filtered from the glomerular capillaries into the Bowman’s capsule per unit time

Symptoms usually occur by stage 4

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13
Q

common causes of chronic renal failure

A 
Glomerulonephritis
Diabetes 
Renovascular disease 
Hypertension
Polycystic disease
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14
Q

management of chronic renal failure

A

Managed under nephrology team. Treat reversible causes. Avoid exacerbating factors, avoid nephrotoxic drugs.
May progress to renal replacement therapy

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15
Q

Glomerulonephritis

A

A group of disorders where there is damage to the glomerular filtration apparatus. This may cause a leak of protein or blood into the urine.

Usually there is a deposition of immune complexes in one part of the nephron

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16
Q

Kidney stones

A

Crystal aggregates that form in the collecting ducts of the kidneys and can deposit anywhere in the renal tract.

Life time incidence 15%

Peak age 20-40 years.

Male: female = 3:1

17
Q

Risk factors for kidney stones

A

Dehydration
Dietary factors ( increase chocolates, tea and rhubarb)
Drugs ( loop diuretics, antacids, corticosteroids, theophylline and aspirin)
Renal tract abnormalities
Recurrent UTIs
Metabolic abnormalities (hyperparathyroidism, hyperthyroidism and cancer)

18
Q

symptoms kidney stones

A

Patient may be asymptomatic (found accidently on x-ray or blood on dipstick ).

Pain. Kidney stones causes loin pain. Ureteric stones case renal colic (from loin to groin). Bladder and urethral stones cause pain on micturition with interrupted flow. Patients often can’t lie still from the pain.

19
Q

management of kidney stones

A

Imaging options: KUB-xray (80% of stones are visible). CT scan (99% of stones visible).

Prompt pain relief

Stones 5mm or causing obstruction may need intervention

20
Q

renal cancer

A

Renal cell carcinoma

85% of all renal cancers.

Usually presents between the ages of 50 and 70 years.

2:1 male predominance .

Smoking an important risk factor along with obesity, hypertension, exposure to asbestos and certain hereditary conditions.

21
Q

renal cancer presentation

A

50% incidental findings on abdominal imaging.

Haematuria.

Loin pain.

Abdominal mass.

Para neoplastic syndromes: e.g. polycythaemia, hypercalcaemia and hypertension.

22
Q

treatment of renal cancer

A

Radical nephrectomy +/- chemotherapy

23
Q

Transitional Cell Carcinoma presentation

A

Classically – painless haematuria

Frequency, urgency and dysuria can occur.

24
Q

Transitional Cell Carcinoma tests

A

Urine for cytology

Cystoscopy and biopsy

25
Q

Transitional Cell Carcinoma treatment

A

Depends on stage of disease and spread

Small lesions at early stage can be managed with diathermy on cystoscopy.

Later stages – radical cystectomy or palliative chemo/radiotherapy

26
Q

Anatomy of Prostate

A

Prostate is a gland that is located at the base of the bladder and around the first part of the urethra.

In normal adults weighs around 20gm.

Helps in the secretion and maintenance of semen and spermatozoa.

27
Q

Benign Prostatic Hyperplasia

A

Common
Hyperplasia: increase in the number of cells.
BPH: increase in number of cell resulting in the formation of nodules. Prostate weighs 60-100gm

28
Q

Benign Prostatic hyperplasia symptoms

A

Usually those of lower urinary tract obstruction: increased frequency, hesitancy, nocturia, terminal dribbling.

Can lead to an increased risk of infection.

Enlarged prostate on PR

29
Q

Benign Prostatic Hyperplasia treatment

A

If small and not symptomatic then conservative, reduce fluid intake (specially at night), reduce alcohol and caffeine, scheduled voiding.
Medical treatment: Alpha-blockers, reduces the smooth muscle tone in the prostate.
TURP (Transurethral Resection of the Prostate)

30
Q

Prostate cancer risk factors

A

Age
Race (more common in black people and very uncommon in Asian people)
Family history
Hormone levels
Diet – increased risk with increased fat consumption

31
Q

Prostate cancer symptoms

A

May be asymptomatic (has a slow course)

Nocturia, hesitancy, poor stream and terminal dribbling

Examination shows a hard irregular prostate

32
Q

Prostate cancer diagnosis

A 
Raised PSA (prostate specific antigen) but may be normal in 30% of cases 
Biopsy
33
Q

Prostate cancer treatment

A

Depends on stage of disease, age of patient and comorbidities

In elderly men with many comorbidities – watchful waiting may be an option

Local disease can be treated with radical prostatectomy

Hormonal therapy and radiotherapy for more advanced cases

34
Q

Testicular torsion

A

Sudden onset of pain in 1 testis.

Pain in abdomen, nausea and vomiting.

Testis is hot, swollen and tender.

The testis may lie high and transversely.

Most common 11-30 years old.

35
Q

Testicular torsion tests

A

Tests: USS with Doppler but may need exploratory surgery

36
Q

Testicular torsion treatment

A

Treatment: Surgery, URGENT, if still viable bilateral fixation (orchidopexy) if abnormal then orchidectomy

37
Q

Testicular tumours

A

Most common malignancy in males aged 15-44 years old.

Risk factors include: undescended testis, infant hernia and infertility.
Presentation: painless testicular lump often noted after trauma or infection
Germ cell tumours
Different categories
Most common is seminoma

38
Q

Testicular tumours treatment

A

Treatment depends on type of tumour and stage

Usually involves an orchidectomy and a combination of radiotherapy and chemotherapy

Pathology (22 decks)

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