Tissue healing

Question 1

What happens in the bleeding phase?

Answer 1

6-8hours, cell death leads to bleeding

Platelets and enzymes plug the area

Vasoconstriction to limit bleeding

Question 2

What happens in the inflammation phase ?

Answer 2

0-72hours

Vasodilation and increased fibrogen and fibrin

Leucocytes, cytokines to regulate lactic acid and stimulate proliferation

Question 3

What happens in proliferation phase?

Answer 3

3days-6weeks

Beginning of angiogenesis

fibroblasts produce type 3 collagen towards area

Scar tissue forms

Granulation tissue contracts wound

New capillary growth and restoration of blood flow, oxygen and nutrients

Question 4

What are the 5 signs of inflammation

Answer 4

Redness - increased flow
Swelling - exudation of fluid
Pain - stretched pain receptors
Heat - exudation of fluid
Loss of function - tissue disruption

Question 5

What happens in remodelling phase?

Answer 5

3 weeks-12moths

Wound matures type 3 collagen into type 1, refinement

Granulation tissue replaced with organised scar tissue

Optimal loading refines the functional pattern of collagen fibres

Question 6

What is angiogenesis?

Answer 6

The development of new blood vessels and capillary growth

Question 7

What is granulation tissue?

Answer 7

The new connective tissue that is formed as a result of angiogenesis, contracts the wound.