Tiotropium

Question 1

type of drug and mechanism

Answer 1

anticholinergic

prevent acetylcholine from binding to muscarinic receptors in the bronchial smooth muscle

(long acting)

Question 2

indications

Answer 2

COPD- prevent exacerbations

severe asthma attacks

Question 3

contraindications

Answer 3

cautious when giving to people with:

• bladder outflow obstruction
• susceptibility to angle-closure glaucoma
• arrhythmia
• heart failure
• previous MI within 6 months

Question 4

interactions

Answer 4

amphetamines (depresses CNS too much)

codeine (risk of adverse effects)

benzodiazepines e.g. diazepam

oxycodone (oxycontin)

Question 5

side effects

Answer 5

dry mouth
constipation
cough
headache
nausea

can increase risk of infection, alter taste