Tick, Mites, Fleas and Lice Flashcards
What phylum do they belong to?
Fleas and lice-
Ticks an mites-
Arthropoda
`insects/6 legs/wingless
Arachnida/8 legs
Ticks
1) Symptoms
2) Treatment
3) Complications
1) None
2) physical removal
3) TBE-viral disease that infects brain
LYMES-bacterial disease (spirochetes) flu-like
Mites
1) Describe life cycle
2) Symptoms
3) Treatment
1) egg, first nymphal install, second nymphal instar (t0 7) adult.
2) itchy, bites in straight lines
3) topical/oral corticosteroids and hygiene
Scabies
1) How is it diagnosed?
2) What is SMIPP
3) What is the 1st and 2nd line treatment and how do these work?
4) why are insects more susceptible
1) Ink test/biopsy
2) Scabies mite inactivated protease paralogue (protein with no enzyme activity) antagonist to PAR 2 on keratinocytes, inhibits inflammatory response
3) Permethrin cream 5% (synthetic pyrethroid, ion channel agonist that works on nervous system, prevents Na+ channel activation)/ Malathion lotion 0.5% (anti cholinesterase, blocks cholinesterase promotes cholinergic transmission continuous muscle contraction, increases muscarinic and nicotinic effects)
4) domain II s4-s5 linked at super-kar site
How does ivermectin work?
Macrolytic lactone
Ion channel agonist, activates GluCl (cos-loop ligand gated ion channel)
GABAaRs & nACHRs
Persistent opening
Fleas
1) Symptoms
2) Treatment
3) Complications
1) Can fly, bites are in clusters
2) antihistamine/cold compress
3) Tungaisis, females burrow into skin, no treatment other than suffocation
Lice
1) Name the three types
2) How can they be detected
1)Pediculus humanus capitis - head
pediculus humanus humanus - body
Phthirus pubis - pubic
2) Black powder, blue spots, blood spots
What are the three treatments for lice and how do they work?
1) Dimeticone - doesn’t kill live eggs, forms water impervious coat and suffocates
2) Malathion - partially ovicidal, neurological toxin
3) Lindane - neurological toxin, inhibits GABAaCl channel complex stopping neurological activity
