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Tropical Medicine > TIck Borne Diseases > Flashcards

TIck Borne Diseases Flashcards

1
Q

frequent clinical manifestations of ricketsiia

A

fever, headache, myalgias, malaise

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2
Q

What are the species of rickettsia

A

Spotted fever-R. Rickettsii, R Conorii, R. Slovaca, R. Africae, R. Parkeri
Typhus: R Prowazekii, R. Typhi

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3
Q

What does R. Rickettsii cause, where is it found

A

Rocky Mountain Spotted Fever, Americas

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4
Q

What does R. Conorii cause, where is it found

A

Mediterranean spotted fever, Africa, Asia Mediterranean

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5
Q

What does R. Africae cause, where is it found

A

African tick bite fever, sub-saharan africa

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6
Q

high fevers, severe disease, rash

A

Rocky Mountain Spotted Fever-Rickettsia rickettsii

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7
Q

How does RMSF cause gangrenous skin/digits

A

damage to microcirculation–>hypovolemia–>gangrene

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8
Q

What is the classic rash of R. Rickettsii

A

Starts on wrists and ankles, progresses to the trunk, commonly involves palms and soles. Will NOT see an inoculation eschar

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9
Q

Which rickettsia causes painless inoculation lesion (eschar); which tick is it?

A

Rickettsia Conorii; brown dog tick (rhipicephalus sanguineus) -Mediterranean spotted fever

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10
Q

Which rickettsiae are the least and most pathogenic

A

African Tick Bite Fever -R Africae (LEAST)–>Mediterranean spotted fever (R. Conorii)–>Rocky Mountain spotted fever (r. Rickettsii)

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11
Q

traveler from south africa, amblyomma tick

A

Rickettsia Africae-african tick bite fever

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12
Q

What tick causes typhus

A

Rickettsia Prowazekii

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13
Q

What ist he brill zinsser disease

A

Recrudescence of rickettsia prowazekii; the susceptible people are advanced age, etoh, immunosuppression, physical stress, malnutrition

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14
Q

What is the vector of Rickettsia Prowazekii

A

Pediculus Humanus Corporis-lives in clothing

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15
Q

What ist he transmission of R. Prowazekii

A

Lice bite, feces, invade through the bite–but if you are febrile, they will move to their neighbors

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16
Q

What is the urban and the suburban cycle of R. Typhi transmission

A

Urban: Rattus species–>xenopsylla cheopis (oriental rat flea)
Suburban cycle: Didelphis (Opossum)–>Ctenocephalides felis (Cat Flea)

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17
Q

What is and where do you find murine typhus

A

Rickettsia Typhi-Latin America (mexico, peru, brazil, colombia)

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18
Q

What are the symptoms of Murine typhus

A

rickettsia typhi-Fever, Headaches, Myalgias, +/- Nausea vomiting, LATE rash; no eschar

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19
Q

How to diagnose rickettsia

A

Recognition, serology IFA, ELISA; PCR (Eschar/buffy coat) ((You wont have ABs int he first week)

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20
Q

Treatment of R. Ricketsii and R. Typhus

A

Doxycycline or chloramphenicol

21
Q

How to treat murine typhus

A

doxycycline or chloramphenicol +/- ciprofloxacin, levofloxacin, azithromycin

22
Q

south indian tamil farmer with 7 days of fever, headache, vomiting, SOB x 24 hours, no recent travel, small black scab in the left groin-no other rash; CSF Protein 103, Glu 56, WBC 65

A

Scrub Typhus: Orientia Tsutsuguamushi

23
Q

What is the scrub typhus name, vector, reservoir

A

Orientia Tsutsugamushi
Vector: chiggers (larva of mite)
Reservoir: Chiggers & Rats

24
Q

patient with papule at bite site of tick, ulcerates, forms an eschar, adenopathy, bite fever, HA, Myalgias and a maculopapular rash

A

Scrub typhus: Papule forms at bite site, papule ulcerates, forms an eschar, local adenopathy

25
Q

O. Tsutsugamushi life cycle

A

6 legged larvae–>8 legged nymphs–>8 legged adults lays eggs–>6 legged larvae–>O. Tsutsugamushi (incubation period is 8-10)

26
Q

What is the epidemiology of scrub typhus

A

Seasonal: warmer months in temperate; dry season in india, year round in tropical; mainly rural village and suburban areas

27
Q

Where is the eschar usually located in Scrub typhus

A

axilla, chest (under breast), abdomen, groin, genitalia

28
Q

South indian man, dry season, eschar under breast

A

Scrub typhus

29
Q

how do you diagnose scrub typhus

A

real time PCR of buffy coat, RDT or ELISA for IGM

30
Q

tx of scrub typhoid

A

doxycycline or tetracycle

31
Q

eschar, hearing loss, pneumonitis, sepsis, CNS involvement with fever in SE Asia

A

Scrub Typhus

32
Q

Rancher with fever, chills, fever, delirium, HA, RLL Crackles; AST is elevated

A

Coxiella BUrnetti, Q favor

33
Q

What is Q fever? What is the source of infection? WHo is at risk?

A

Caused by coxiella burnetti; small gram negative coccobacillus; infected caattle, sheep, goats; has high concentration in placenta; inhaled by humans; Vets, farmers are at risk

34
Q

transmission of coxiella (Q fever)

A

aerosol, farming, slaughtering animals

35
Q

What are the clinical symptoms of Q fever

A

CAP, Hepatitis, Flu-like illness, endocarditis, vasculopathy, osteomyelitis ; elevated ESR, Thrombocytopenia, hepatitis, elevated LFTs

36
Q

how do you diagnose Q fever

A

Serology, PCR

37
Q

Treatment of Q fefver

A

doxycycline

38
Q

Tick Borne Zoonotic viral hemorrhagic fever from India

A

Kyasunar Forest Disease -tick borne viral hemorrhagic fever; single stranded RNA –>high mutations

39
Q

Incubation period of KFD

A

3 days, sudden onset febrile illness, GI symptoms, bleeding

40
Q

What is the common flavivirus presentation

A

BiPhasic course

41
Q

What is the prevention for KFD

A

Formalin inactivated vaccine (vax 5km radius)
Deet

42
Q

What is the vector for murine typhus

A

rat flea feces

43
Q

R prowazekii vector

A

pediculus humanus (feces)

44
Q

Rickettsial Pox

A

Akari

45
Q

Rickettsia Conorii

A

Africa, Europe, America, mediterranean

46
Q

Rickettsia typhi-vector

A

FLEA Feces

47
Q

Ricketssia Akari Vector

A

Mite

48
Q

Rickettsia Conorii Vector

A

ticks

Tropical Medicine (19 decks)

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