thyroid pharm Flashcards

1
Q

what treatments are available for hypOthyroidism?

A

Levothyroxine (T4)
Liothyronine (T3)
Dessicated thyroid (T4/T3)

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2
Q

What are symptoms of excess?

A
irritability
inc. HR, contractility, HTN, palpitations
diarrhea
dec. bone mineral density
hair loss
inc. sweating
weight loss/ heat intolerance
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3
Q

what are symptoms of deficit?

A
depression, lethargy
dec. HR, HF, hypotension, shock
constipation
mm pain, weakness and fatigue
brittle hair or nails, dry skin
weight gain
cold intolerance
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4
Q

Compare the onset of levothyroxine vs. liothyronine

A
levothyroxine = 3-5 days
liothyronine = 4 hours
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5
Q

what are treatments for hypERthyroidism?

A

PTU
Methimazole
Potassium iodide

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6
Q

what’s the MOA of potassium iodide (high dose I-)?

A

“Wolff-Chaikoff effect”: inhibition of

NIS, TPO, hormone release

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7
Q

what is the MOA of methimazole?

A

inhibits thyroid peroxidase

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8
Q

what is the MOA of propylthiouracil (PTU)?

A

inhibits TPO and 5’ deiodinase conversion of T4 to T3

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9
Q

Compare protein binding in methimazole vs PTU

A
methimazole = none! (excreted in breast milk and crosses placenta)
PTU = 60-80% (less excreted in milk)
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10
Q

Compare dosing of methimazole vs. PTU

A

methimazole: daily
PTU: q8hrs

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