Thyroid Nodules Flashcards
1
Q
Benign thyroid neoplasms
A
adenoma
2
Q
Malignant thyroid neoplasms
A
- Papillary (85-90%): multifocal, LN
- Follicular/Hurthle (5%): vascular spread
- Anaplastic (<2%): very aggressive
- Medullary (5%): familial
- Lymphoma (rare)
- Sarcoma (rare)
- Metastatic (rare)
3
Q
Thyroid adenoma
A
Benign neoplasm Solitary nodule Follicular / Hurthle cell DDx: hyperplastic nodule or follicular ca Careful evaluation of the capsule
4
Q
2 types of Follicular/Hurthle cell Carcinoma
A
- Minimally invasive: Vascular or capsular invasion
- Widely invasive: More extensive invasion
5
Q
Papillary Carcinoma
A
Most common Well-differentiated Multifocal Lymphatic spread Excellent prognosis
6
Q
Papillary carcinoma path
A
Papillae with vascular core Optically clear nuclei Nuclear pseudoinclusions Nuclear grooves Rare or absent mitoses Psammoma Bodies
7
Q
Anaplastic carcinoma
A
Older age group (poor survival)
Rapidly growing mass
Necrosis and hemorrhage
3 patterns
8
Q
Three patterns of anaplastic carcinoma
A
Spindle cell
Giant cells
Squamoid cells
9
Q
Medullary carcinoma
A
Solid proliferation of cells with granular cytoplasm (C cells)
Highly vascular stroma
Hyalinized collagen and/or amyloid
May have Psammoma bodies
10
Q
Medullary carcinoma Immunostains:
A
Thyroglobulin -,
Calcitonin +,
Chromogranin +
11
Q
Thyroid gland lymphoma
A
Background autoimmune thyroiditis Large fleshy masses DDx : anaplastic ca of thyroid Positive LCA, usually B-cell Gene rearrangement
12
Q
Look at slide histo
A
will do
