BRS Pharm & Physio

Question 1

Somatostatin inhibits the release of

Answer 1

growth hormone and thyroid-stimulating hormone (TSH) from the pituitary

Question 2

Octreotide is used to treat

Answer 2

• acromegaly;
• severe diarrhea associated with hypersecretory states
• upper GI bleeding; and
• TSH-secreting adenomas.

Question 3

Lanreotide

Answer 3

long-acting somatostatin analog

Question 4

Chronic administration of GnRH

Answer 4

inhibits the release of both LH and FSH by causing a reduction in the number of GnRH receptors.

Question 5

Drugs that reduce (CNS) dopaminergic activity cause

Answer 5

increase in prolactin secretion:

(1) Antipsychotics,includingchlorpromazineandhaloperidol
(2) Antidepressants,includingimipramine
(3) Antianxietyagents,includingdiazepam

Question 6

Prolactin-releasing factor (PRF)

Answer 6

Several peptides, including thyrotropin-releasing hormone (TRH)

Question 7

Bromocriptine

Answer 7

an agonist of dopamine D2-receptors and an antagonist of D1-receptors.

Question 8

Cabergoline

Answer 8

It is more effective

in reducing hyperprolactinemia than bromocriptine and has a long half-life that permits twice-weekly dosing.