Thyroid Management Flashcards
1
Q
levothyroxine moa
A
mimics endogenous t4
2
Q
levothyroxine healthy adults dose
A
1.6 mcg/kg/d
3
Q
levothy 50-60 yrs, no cardiac dose
A
50 mcg daily
4
Q
levothy w cvd
A
12.5-25 mcg/d, titrate up
5
Q
levothy titration
A
25mcg/day increments
6
Q
levothy AE
A
- cardiac abnormalities
- fracture
- signs hyperthyroidism
7
Q
levothy administration
A
EMPTY STOMACH
- 30-60mins before bf / 4hrs after dinner
- calcium / iron supplements / antacid -> at least 2 h apart
7
Q
levothy monitoring
A
4-8 weeks (TSH)
8
Q
target TSH
A
0.4 to 4 mIU/L
9
Q
thionamides (carbimazole, PTU) moa
A
inhibits iodination and synthesis of thyroid hormones
10
Q
ptu dosing
A
PO 50-150mg TDS
11
Q
thioamides ptu euthyroid dosing
A
PO 50mg BD / TDS
12
Q
thioamides carbimazole dosing
A
PO 15-60mg in 2-3 doses
13
Q
thioamides carbimazole euthyroid
A
PO 5-15mg OD
14
Q
thioamides AE
A
hepatotoxicity (esp PTU)
rash (SJS)
low WBC
