Men's Health - ED

Question 1

physiology of erection

Answer 1

ACh > NO > guanylate cyclase > cGMP
ACh + pgE > adenyl cyclase > cAMP

leads to SM relaxation and VD > blood inflow

Question 2

physiology of detumescence

Answer 2

deactivation of parasymp (cGMP deactivate PDE5, stops VD)

activation of symp (induces SM contraction and reduces blood flow)

Question 3

what to check for in ED pts

Answer 3

cardiac fx

Question 4

pde5i uses

Answer 4

causes erection upon sexual stimulation

Question 5

pde5i ddi

Answer 5

cyp3a4i, alpha blockers

Question 6

pde5i se

Answer 6

priapisms (seek TX within 4h),
headache
hearing loss
ocular issues

Question 7

pde5i advice

Answer 7

do not give up after one failed dose

Question 8

pde5i ci

Answer 8

nitrates

Question 9

which pde5i must take before sex?

Answer 9

(1h before) sildenafil, vardenafil
(30min before) avanafil

Question 10

pde5i without food

Answer 10

silde, varde

Question 11

pde5i dosing adj hep

Answer 11

s,v,t

Question 12

pde5i dosing renal

Answer 12

s, t

Question 13

varde se

Answer 13

ocular, qtc prolong

Question 14

silde se

Answer 14

ocular

Question 15

tada se

Answer 15

muscle pain

Question 16

tts replacemt indication

Answer 16

1. decreased libido
2. low serum tts

Question 17

tts repl se

Answer 17

irritability, aggression, hair growth, raised BP, hepato

Question 18

tts repl discontinue

Answer 18

after 3 mths

Question 19

pge1 analogs (alprostadil) moa

Answer 19

stimulates adenyl cyclase > cAMP > SM relax > erection

Question 20

pge 1 onset

Answer 20

10 min

Question 21

pge 1 issues

Answer 21

abnormal erection , priapism

Question 22

pge 1 intraurethral se

Answer 22

pain, bleeding, burning sensation, vaginal itch in partner, priapism

Question 23

pge 1 intracavernosal se

Answer 23

priapism, needle usage, invasiveness