Thyroid Hormones and Anti-thyroid Drugs Flashcards
more potent, less highly protein bound, much shorter half-life
T3
less potent, more protein bound, much longer half-life
T4
T3
liothyronine
T4
levothyroxine
____ is 5X more potent that ___
T3, T4
thyroid physiological effects are mainly due to
T3
what type of receptor do T3 and T4 act on?
nuclear
the more “natural” thyroid replacement
dessicated thyroid
used in surgery for thyroid cancer, maintain suppressive effects while patients are tapered off of other thyroid replacement; short-term support prior to radioiodine
liothyronine
patients may need to increase or decrease dose of thyroid during pregnancy, or stay away form it altogether?
increase
preferred treatment of myxedema coma
levothyroxine
this drug inhibits the peroxidase enzyme, inhibiting iodination and thyroid coupling steps
PTU (propylthiouracil), MMI (methimazole)
this drug inhibits conversion of T4 to active T3
PTU
useful for immediate control of thyroid hormone production, but not already pre-released TH
PTU, MMI
this anti-thyroid is less potent, has a short half-life
PTU
this anti-thyroid is more potent, longer acting
MMI
what is the better anti-thyroid due to one-a-day dosing and longer plasma half life, non-liver-toxic?
MMI
which anti-thyroid is liver toxic?
PTU
PTU and MMI can both cause this, symptoms are sore throat and feve
agranulocytosis
1st trimester of pregnancy, thyroid storm, which drug do you use?
PTU
used in radiation emergencies to compete for uptake of radioactive materials
KI
small doses in tracer studies of uptake for diagnosis of hyperthyroidism, localization of metastatic thyroid cancer
radioactive iodine
large doses used for destruction of thyroid tissue without damage to other organs
radioactive iodine
what drugs are given prior to scheduled radio-iodine treatment? Used to lower TH, increase TSH to maximize radioiodine uptake and also reduce risk of thyroid storm
MMI, PTU
