Hypothalamic/Pituitary Hormones: Peptide Drugs

Question 1

this peptide drug was once derived from human cadaver material, but was withdrawn due to Creutzfeldt-Jacob syndrome (MAD COW). Now only recombinant products used

Answer 1

somatropin

Question 2

Identical to human growth hormone, activates GH receptor coupled to Jak-STAT

Answer 2

somatropin

Question 3

Used for replacement therapy; children with GH deficiency

Answer 3

somatropin

Question 4

turner’s syndrome, Prader-willi syndrome, AIDs cachexia, short bowl sydrome are other APPROVED uses

Answer 4

somatropin

Question 5

Laron form of dwarfism has a ____ receptor defect

Answer 5

GH

Question 6

this peptide drug is administered nasally in GH deficient patients

Answer 6

sermorelin

Question 7

Activates GHRH GPCR receptor; stimulates endogenous GH release, indirectly stimulating IGF-1 release and growth

Answer 7

sermorelin

Question 8

Laron form of dwarfism would use this peptide drug where GH and GHRH is not working

Answer 8

mecasermin

Question 9

synthetic recombinant human IGF-1

Answer 9

mecasermin

Question 10

directly stimulates IGF-1 receptor; bypasses hypothalamus and pituitary signals

Answer 10

mecasermin

Question 11

Used in children with developed-antibody-mediated resistance to GH replacement therapy.

Answer 11

mecasermin

Question 12

HYPOGLYCEMIA, OVERGROWTH OF FACIAL BONES, KIDNEY PROBLEMS

Answer 12

mecasermin

Question 13

inhibits GH release, but also TSH, prolactin, insulin/glucagon, and gut peptides (inhibits GI motility)

Answer 13

octreotide

Question 14

endogenous somatostatin peptide drug

Answer 14

octreotide

Question 15

activates SST GPCR receptors

Answer 15

octreotide

Question 16

Used in acromegaly (excess GH), various hormone-secreting tumors

Answer 16

octreotide

Question 17

direct growth hormone receptor ANTAGONIST

Answer 17

pegvisomant

Question 18

treats acromegaly in patients who fail with surgery, radiation, and other drugs

Answer 18

pegvisomant

Question 19

endogenous inhibitor of prolactin release

Answer 19

dopamine

Question 20

parkinsons disease medications that stimulate dopamine release inhibit the release of?

Answer 20

prolactin

Question 21

antipsychotic medications that inhibit dopamine release increase the release of?

Answer 21

prolactin

Question 22

not a peptide drug; orally effective

Answer 22

cabergoline

Question 23

stimulates dopamine release and thus; inhibiting prolactin release

Answer 23

cabergoline

Question 24

selective to D-2 GPCR receptors

Answer 24

cabergoline

Question 25

treats infertility from hyperprolactinemia, suppression of lactation

Answer 25

cabergoline

Question 26

this drug inhibits GH release in acromegaly, but stimulates GH release in normal subjects

Answer 26

cabergoline

Question 27

synthetic peptide identical to natural vasopressin hormone

Answer 27

AVP (arginine vasopressin)

Question 28

targets V1 and V2; resulting effects from both of these receptors

Answer 28

AVP (arginine vasopressin)

Question 29

preferred agent for V1-receptor related applications; short duration of action

Answer 29

AVP (arginine vasopressin )

Question 30

agent for TEMPORARY DI following pituitary surgery; a V-2 effect, but short action makes this drug appropriate

Answer 30

AVP (arginine vasopressin)

Question 31

used for local administration for constriction of a bleeding artery; also prevents various forms of hemorrhage; vasoconstriction in resuscitation of v-tach and v-fib

Answer 31

AVP (arginine vasopressin)

Question 32

side effects include increased blood pressure; also causes uterine contractions due to cross-reactivity @ oxytocin receptors

Answer 32

AVP (arginine vasopressin)

Question 33

modified vasopressin analog; much longer DOA

Answer 33

desmopressin

Question 34

the FIRST orally administered peptide drug

Answer 34

desmopressin

Question 35

selective for the V2 vasopressin receptor

Answer 35

desmopressin

Question 36

replacement therapy in diabetes insipidus; hemophilia, and von-wildebrands disease

Answer 36

desmopressin

Question 37

Feed-forward inhibition

Answer 37

GH, PRL

Question 38

given prior to epiphysial closure

Answer 38

somatropin