thyroid hormone: synthesis, storage, and release

Question 1

during iodine ion uptake where is the iodine ion moved from

Answer 1

the blood

Question 2

during iodine ion uptake once the iodine ion is moved from the blood what does it go across

Answer 2

2 membranes of the follicular cell

Question 3

during iodine ion uptake once the iodine ion is moved from the blood and goes across 2 membranes of the follicular cell what does it go into

Answer 3

into the follicular lumen by active transport and facilitated diffusion

Question 4

what happens to the iodine ion during iodine ion formation

Answer 4

two iodine ions are joined

Question 5

during iodine ion formation after the two iodine ions are joined what do they form

Answer 5

molecular ions at the plasma membrane of the follicular cell

Question 6

during thyroglobulin synthesis what is synthesized

Answer 6

concurrently, thyroglobulin protein molecules are synthesized

Question 7

during thyroglobulin synthesis where are the thyroglobulin protein molecules synthesized

Answer 7

within the rough ER

Question 8

during the thyroglobulin once the thyroglobulin protein molecules are synthesized within the rough ER where are they shipped to

Answer 8

Golgi apparatus for modification

Question 9

during thyroglobulin once the thyroglobulin protein molecules are synthesized within the rough ER and and then shipped to the Golgi apparatus for modification what are they transported by

Answer 9

vesicles and released from the follicular cell into the colloid by exocytosis

Question 10

what happens in the follicular cell during endocytosis

Answer 10

thyroglobulin molecules with iodine molecules attached to its tyrosine amino acids are moved into a follicular cell by endocytosis

Question 11

what is the first step is the release of t3 and t4 from the thyroglobulin

Answer 11

vesicle containing thyroglobulin with attached pre t3 and pre t4 fuses with a lysosome

Question 12

what is the 2nd step in the release of t3 and t4 from thyroglobulin

Answer 12

lysosomal enzymes cleave pre t3 and pre t4 from the thyroglobulin

Question 13

what is the first step in the release of t3 and t4 into the blood

Answer 13

t3 and t4 which are lipid soluble molecules move from the follicular cell into the blood by simple diffusion

Question 14

what is the 2nd step in the release of t3 and t4 into the blood

Answer 14

more t4 is released from t3, t3 and t4 are collectively called the thyroid hormone

Question 15

what are the steps in the synthesis, storage, and release of the thyroid hormone

Answer 15

1. iodine ion uptake
2. iodine molecule formation
3. thyroglobulin synthesis
   4.culloid
4. endocytosis
   6.release of t3 and t4 from the thyroglobulin
   7.release of t3 and t4 into the blood