Thyroid Hormone Flashcards
Metabolic effects of TH
1) Heat regulation
2) NA+/K+ ATPase pump regulation
3) Modulate BMR
4) Anabolic and Catabolic effects
Anabolic effects of TH
1) Glucose –> glycogen
2) Protein synthesis
3) Store fat
Catabolic effects of TH
1) Glycogen –> glucose
2) Protein breakdown
3) Fat breakdown
Cardiovascular effects of TH
1) Increase heart responsiveness to catecholamines
2) Increase heart rate
3) Force heart contraction
4) Increase vasodilation
Growth effects of TH
1) Stimulate GH secretion
2) Promote GH and IGF effects
3) Low TH = stunted growth
Symptoms of lack of TH
1) feel cold
2) weight gain
3) hair loss
4) puffy face
5) dry skin and hair
Causes of lack of TH
1) Damage to thyroid gland and not producing TH
2) Damage to TSH and not producing enough TSH
3) Not enough iodine
4) Not enough TRH
5) Hypothalamus damage
Treatment for lack of TH
1) Iodine supplement
2) Thyroid hormones
Symptoms of excess TH
1) increased BMR
2) heat intolerant
3) weight loss
4) irritability
5) heart failure due to increase cardiac output
Causes of excess TH
Inflammation or excessive growth of thyroid
Treatment for excess TH
1) Radioactive iodine to selectively kill thyroid
2) Surgical removal of thyroid
3) Anti-thryoid drugs
4) Low iodine diet