Thyroid Drugs Flashcards
Levothyroxine is used to treat
Hypothyroidism, goiters, cretinism, myxedema coma
Propylthiouracil (PTU) is used to treat
Hyperthyroidism (Graves Disease & Plummer disease aka toxic nodular disease
Contraindications to use of Levothyroxine
Recent MI, adrenal insufficiency, and hyperthyroidism
Should Levothyroxine be taken with food?
No, take on empty stomach in morning 30-60 min before breakfast
Levothyroxine is dosed in what unit
micrograms
signs of OD of Levothyroxine
tachycardia, angina, tremor, nervousness, insomnia, hyperthermia, heat intolerance, sweating
Levothyroxine has what effect on warfarin
increases effect
Levothyroxine has what effect on catacholamines (epinephrine, dopamine, dubutamine)
increase cardiac response and induce dysrhythmias and bone loss
are Levothyroxine preparations interchangeable
No, pt. should stay on same brand or generic name. If switch made retest TSH in 6 wks to adjust dosage
Propylthiouracil adverse effects
liver and bone marrow toxicity
Propylthiouracil given in what form
Oral
Is Propylthiouracil safe for Pregnancy
It should be avoided
when do therapeautic effects of Propylthiouracil take place
Can take approx. 2 weeks
what should you monitor when admin Propylthiouracil
Baseline weight, I&O, and thyroid storm (tachycardia, cardiac irregularities, fever, HF, flushed skin, confusion, behavioral change, HoTN
Propylthiouracil contraindicated with
anticoagulants and meds leasing to bone marrow supression
