Antilipemics

Question 1

most commonly used drug for cholesterol lowering

Answer 1

Atorvastatin (lipitor)

Question 2

antilipemics contraindicated in

Answer 2

liver dysfunction, elevated transaminase levels, pregnancy category x,

Question 3

Atorvastatin (lipitor) indication

Answer 3

lower LDL cholesterol as well as triglycerides. It also raises HDL componenet

Question 4

Antilipemics dosing

Answer 4

once daily usually w/ evening meal or at bedtime

Question 5

Atorvastatin (lipitor) advantage

Answer 5

can be dosed any time of day

Question 6

how long does treatment continue for statins?

Answer 6

Lifelong: LDL levels will return w/i weeks to months

Question 7

SE of statins

Answer 7

Increasede bone formation (reduce risk of osteoporosis) reduce risk of CV events

Question 8

Potential uses for statins

Answer 8

Diabetes, CVD, MI therapy

Question 9

SE of statins

Answer 9

well tolerated and SE uncommon. Some pt. have headache, rash or GI disturbance

Question 10

Seriouse AE of statins

Answer 10

hepatotoxicity and myopathy

Question 11

Tests to perform w/ statins

Answer 11

Liver function test before treatment and q6-12 months after that.

Question 12

Lipitor and Zocor drug interaction

Answer 12

CYP3A4 will raise levels of statin (erythromycin and antifungals like ketoconazole)

Question 13

contraindication Lipitor

Answer 13

significant renal impairment