Thyroid

Question 1

What happens to TSH, T3, T4 levels in hypothyroidism?

Answer 1

TSH increases, T3 and T4 decreased.

Question 2

Name the functions of T3, the 4B’s?

Answer 2

Brain maturation, Bone metabolism, Basal metabolic rate, Beta adrenergic effects.

Question 3

what stimulates the thyroid and where does this hormone come from?

Answer 3

TSH from the anterior pituitary. (Thyrotropin Releasing Hormone from the hypothalamus stimulates the TSH from anterior pituitary)

Question 4

of T3 and T4, which one is active form and inactive form and where are they converted from one to the other and by what enzyme?

Answer 4

• -T4 is inactive
• -T3 is active
• -T4 is converted to T3 in peripheral tissues by 5 Deiodinase

Question 5

how do T3 and T4 travel around the body, bound to?

Answer 5

thyroxine binding globulin TBG

Question 6

where is TBG made

Answer 6

in the liver

Question 7

name conditions where levels of TBG is increased and decreased?

Answer 7

increased in pregnancy and OCP use (estrogen)

decreased in liver failure

Question 8

in hyperthyroidism what happens to the following
TSH
T3, T4 levels
cholesterol levels

Answer 8

TSH- decreased
T3, T4 increased
cholesterol- hypocholesterol