Thursday 2 - case - this is just on the final i guess wtf Flashcards
First test you do in tesing for HIV? second test?
first - ELISA second - HIV western blot
tests used to follow Tx of HIV
Viral load test CD4 count
most common opportunistic infection in HIV Patients
pneumocystis
what type of genome does NIV have important genes
two copoies of the positive polarity ssRNA less than 10,000 BP has multiple overlapping reading frames Genes and what they encode: GAG: capsid proteins - this is what ELISA is usually looking for POL: reverse transcriptase, protease, integrase ENV: enveloped glycoproteins they are made into huge proteins that require cutting by protease in order to make the effective lengths of proteins
capsid of HIV
icosahedral
Enveloped status of HIV
enveloped, Envelope includes gp120, gp41
mechanism of first entry of HIV into cells of the body
macrophages. goes on to infect CD4 t cells by binding to the CD4 receptors
3 enzymes that come with the viral particel
reverse transcriptase integrase protease
why are certain people “immune” to getting infected with HIV
Stromal derived factor 1 (SDF1) is produced by stromal cells, acts as chemoattractant. causes lymphocyte to migrate towards the site of SDF production. (i.e. cells who are being infected by HIV)
What is the DNA polymerase in HIV
it is the same enzyme as the reverse transcriptase. It can make DNA from RNA or DNA.
after HIV integration into the host genome to become a provirus, what enzyme produces HIV mRNA and genomic RNA
host RNA pol II
What measurable antigen goes up first when you get infected with HIV
P24
When a CD4 pos t cell receptor is activated, what Transcri
NFKB
Diagram the mechanism by which HIV gets into a cell and makes more HIV
Sorry if the picture is small
