Interleukins 1 - 10 Flashcards
IL-1
producer cells
target cells
principle effects
produced by macrophages
targets: T, B, Macrophages, Endothelium, Tissue cells
Effects: Endogenous pyrogen. Osteoclast-activating factor. Causes fever and acute inflammation. Activates endothelium to express adhesion molecules. Induces chemokine secretion to recruit leukocytes
IL-2
producer cells
target cells
principle effects
Producer: T cells
Target: T cells
Effects: Stimulates the growth and differentiation of helper, cytotoxic, and regulatory T cells. Activates macrophages.
IL-3
producer cells
target cells
principle effects
Producer: T cells
Target cells: Bone marrow stem cells
Effects: Supports the growth and differentiation of bone marrow stem cells. Functions as a multilineage colony stimulating factor.
IL-4
producer cells
target cells
principle effects
Producer: Th2 T cells
Target: B and T cells
Effects: Induce the differentiation of T cells into Th2 cells. Promotes the growth of B cells. Enhances class switching to IgE and IgG(1)
(Also promotes basophils)
IL-5
producer cells
target cells
principle effects
Producer: Th2 T cells
Target: B cells
Effects: Promotes the differentiation of B cells. Enhances class switching to IgA. Stimulates the growth and differentiation of eosinophils.
IL-6
producer cells
target cells
principle effects
Producer: Th2 cells and macrophages
Target: Hepatocytes
Effects: Endogenous pyrogen. stimulates production of acute-phase proteins
IL-7
producer cells
target cells
principle effects
Producer: Stromal cells in the bone marrow and thymus
Target: Pre-B and T cells
Effects: B cell and T cell proliferation
IL-8
producer cells
target cells
principle effects
Producer: macrophages
Target: Neutrophils
Effects: major chemotactic factor for neutrophils.
IL-9
producer cells
target cells
principle effects
Producer: T cells
targets: T cells and mast cells
Effects: enhances T cell survival. Activates mast cells. Works in synergy with erythropoietin.
IL-10
producer cells
target cells
principle effects
Producer: Th2 and Treg T cells
Target: T cells
Effects: inhibits T cells. Similar to TGF-beta in inhibiting inflammation
